Evidence map›Paper›PMID 35109869›Full record

ArticleJournal of neuroinflammation2022

Neurodegeneration in the centrally-projecting Edinger-Westphal nucleus contributes to the non-motor symptoms of Parkinson's disease in the rat.

Balázs Ujvári, Bence Pytel, Zsombor Márton, Máté Bognár, László Ákos Kovács, József Farkas, Tamás Gaszner, Gergely Berta, Angéla Kecskés, Viktória Kormos and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

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  9. Exercise-Activated mPFC Tri-Synaptic Pathway Ameliorates Depression-Like Behaviors in Mouse.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  16. The pathobiological basis of depression in Parkinson disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  17. Microglia as Central Protagonists in the Chronic Stress Response.Neurology(R) neuroimmunology & neuroinflammation · 2022
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Balázs UjváriDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
Bence PytelDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
Zsombor MártonDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
Máté BognárDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
László Ákos KovácsDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
József FarkasDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
Tamás GasznerDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
Gergely BertaDepartment of Medical Biology, Medical School, University of Pécs, 7624, Pecs, Hungary.
Angéla KecskésDepartment of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, University of Pécs, 7624, Pecs, Hungary.
Viktória KormosDepartment of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, University of Pécs, 7624, Pecs, Hungary.
Boglárka FarkasDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
Nóra FürediDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary.
Balázs GasznerDepartment of Anatomy, Research Group for Mood Disorders, Medical School, University of Pécs, Szigeti út 12., 7624, Pecs, Hungary. balazs.b.gaszner@aok.pte.hu.ORCID http://orcid.org/0000-0003-2830-2732
University of Pecs · HU

Funding

általános orvostudományi kar, pécsi tudományegyetem KA-2019-12általános orvostudományi kar, pécsi tudományegyetem KA-2020-03általános orvostudományi kar, pécsi tudományegyetem KA-2021-23magyar tudományos akadémia János Bolyai Research ScholarshipMinistry for Innovation and Technology in Hungary Thematic Excellence Program 2021 EGA-16nemzeti kutatási és technológiai hivatal FK124188nemzeti kutatási, fejlesztési és innovaciós alap TKP2020-IKA-08nemzeti kutatási, fejlesztési és innovaciós alap ÚNKP-20-4-II-PTE-874new national excellence program of the ministry for innovation and technology from the source of the national research, development and innovation fund ÚNKP-20-4-II-PTE-547
6 · The paper itself

Abstract

backgroundThe neuropathological background of major depression and anxiety as non-motor symptoms of Parkinson's disease is much less understood than classical motor symptoms. Although, neurodegeneration of the Edinger-Westphal nucleus in human Parkinson's disease is a known phenomenon, its possible significance in mood status has never been elucidated. In this work we aimed at investigating whether neuron loss and alpha-synuclein accumulation in the urocortin 1 containing (UCN1) cells of the centrally-projecting Edinger-Westphal (EWcp) nucleus is associated with anxiety and depression-like state in the rat.

methodsSystemic chronic rotenone administration as well as targeted leptin-saporin-induced lesions of EWcp/UCN1 neurons were conducted. Rotarod, open field and sucrose preference tests were performed to assess motor performance and mood status. Multiple immunofluorescence combined with RNAscope were used to reveal the functional-morphological changes. Two-sample Student's t test, Spearman's rank correlation analysis and Mann-Whitney U tests were used for statistics.

resultsIn the rotenone model, besides motor deficit, an anxious and depression-like phenotype was detected. Well-comparable neuron loss, cytoplasmic alpha-synuclein accumulation as well as astro- and microglial activation were observed both in the substantia nigra pars compacta and EWcp. Occasionally, UCN1-immunoreactive neuronal debris was observed in phagocytotic microglia. UCN1 peptide content of viable EWcp cells correlated with dopaminergic substantia nigra cell count. Importantly, other mood status-related dopaminergic (ventral tegmental area), serotonergic (dorsal and median raphe) and noradrenergic (locus ceruleus and A5 area) brainstem centers did not show remarkable morphological changes. Targeted partial selective EWcp/UCN1 neuron ablation induced similar mood status without motor symptoms.

conclusionsOur findings collectively suggest that neurodegeneration of urocortinergic EWcp contributes to the mood-related non-motor symptoms in toxic models of Parkinson's disease in the rat.

Indexed as

Edinger-Westphal NucleusParkinson DiseaseAnimalsAnxietyHumansNeuronsRatsUrocortinsUrocortinsAnxietyDepressionImmunofluorescenceRatRNAscopeRotenoneSaporinUrocortin 1

Identifiers

PMID35109869
PMCPMC8809039
OpenAlexW4210353761

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.