Evidence map›Paper›PMID 35109713›Full record

ArticleAIDS research and human retroviruses2022

Class-Based Antiretroviral Exposure and Cognition Among Women Living with HIV.

Amanda Blair Spence, Chenglong Liu, Leah Rubin, Bradley Aouizerat, David Eugene Vance, Hector Bolivar, Cecile Delille Lahiri, Adaora A Adimora, Kathleen Weber, Deborah Gustafson and 3 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Amanda Blair SpenceDivision of Infectious Diseases, Georgetown University Medical Center, Washington, District of Columbia, USA.ORCID 0000-0001-9011-8456
Chenglong LiuDivision of Infectious Diseases, Georgetown University Medical Center, Washington, District of Columbia, USA.
Leah RubinDepartment of Neurology and John Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2749-6328
Bradley AouizeratDepartment of Oral and Maxillofacial Surgery, College of Dentistry, New York University, New York, New York, USA.
David Eugene VanceSchool of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Hector BolivarDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Cecile Delille LahiriDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine and Grady Healthcare System, Atlanta, Georgia, USA.
Adaora A AdimoraSchool of Medicine and UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kathleen WeberCook County Health/Hektoen Institute of Medicine, Chicago, Illinois, USA.
Deborah GustafsonDepartment of Neurology, State University of New York-Downstate Health Sciences University, Brooklyn, New York, USA.
Oluwakemi SosanyaDepartment of Medicine, Montefiore Medical Center, Bronx, New York, USA.
Raymond Scott TurnerDepartment of Neurology, Georgetown University Medical Center, Washington, District of Columbia, USA.ORCID 0000-0001-7534-2935
Seble KassayeDivision of Infectious Diseases, Georgetown University Medical Center, Washington, District of Columbia, USA.
Georgetown University · USCenter for Clinical Research (United States) · USGrady Memorial Hospital · USHektoen Institute · USJohns Hopkins University · USMontefiore Medical Center · USSUNY Downstate Health Sciences University · USUniversity of Alabama at Birmingham · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · US

Funding

Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
University of Pittsburgh MWCCS Clinical Research SiteU01HL146208 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bernard Jonas C Macatangay, CHARLES R RINALDO · 2019 to 2026
$32.2M
Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort StudyU01HL146333 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roger Detels, Matthew James Mimiaga · 2019 to 2026
$32.2M
Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS ResearchU01HL146240 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Frank J Palella, Valentina Stosor · 2019 to 2026
$31.5M
SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6M
MACS/WIHS Combined Cohort Study Clinical Research SiteU01HL146241 · NHLBI · EMORY UNIVERSITY · PI Cecile Delille Lahiri, Anandi Nayan Sheth · 2019 to 2026
$24.2M
UAB-MISS MACS/WIHS Combined Cohort StudyU01HL146192 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James Benjamin Brock, MIRJAM-COLETTE KEMPF · 2019 to 2026
$23.9M
MWCCS: Brooklyn Clinical Research SiteU01HL146202 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI TRACEY ELIZABETH WILSON, Jessica Eve Yager · 2019 to 2026
$23.6M
NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI117970NIAID NIH HHS U01 AI031834
6 · The paper itself

Abstract

Neurologic complications of the human immunodeficiency virus (HIV) are common in treated individuals, and toxicity of certain antiretroviral therapies (ART) may contribute to cognitive impairment. We investigated exposures to specific ART and cognition among women living with HIV (WLWH). Virologically suppressed (viral load <200 copies/mL during at least two semi-annual visits) WLWH and age/race matched HIV-seronegative controls enrolled in the Women's Interagency HIV Study who completed at least two biennial cognitive assessments were included. Analysis of WLWH was restricted to those with exposure to the drug class of interest and a nucleoside reverse transcriptase inhibitor (NRTI) backbone. Generalized estimating equations were used to evaluate repeated measures of cognition over time in association with ART class exposure. Among 1,242 eligible WLWH, 20% (

Indexed as

Anti-HIV AgentsHIV InfectionsAnti-Retroviral AgentsCognitionFemaleHumansReverse Transcriptase InhibitorsViral LoadAnti-HIV AgentsAnti-Retroviral AgentsReverse Transcriptase Inhibitorsantiretroviral therapyantiretroviral toxicitycognitive impairmentHIV and aging

Identifiers

PMID35109713
PMCPMC9297324
OpenAlexW4210582699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.