Evidence map›Paper›PMID 35109711›Full record

ArticleJournal of neurotrauma2022

Combined Inhibition of Fyn and c-Src Protects Hippocampal Neurons and Improves Spatial Memory via ROCK after Traumatic Brain Injury.

Zhouheng Ye, Ali Izadi, Gene G Gurkoff, Kaitlin Rickerl, Frank R Sharp, Bradley P Ander, Sawyer Z Bauer, Austin Lui, Bruce G Lyeth, DaZhi Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Post-Translational Modifications in Traumatic Brain Injury: Decoding the Proteomic Landscape and Molecular Mechanisms of Secondary Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zhouheng YeDepartment of Neurology, University of California at Davis, Sacramento, California, USA.
Ali IzadiDepartment of Neurological Surgery, University of California at Davis, Sacramento, California, USA.
Gene G GurkoffDepartment of Neurological Surgery, University of California at Davis, Sacramento, California, USA.
Kaitlin RickerlDepartment of Neurology, University of California at Davis, Sacramento, California, USA.
Frank R SharpDepartment of Neurology, University of California at Davis, Sacramento, California, USA.
Bradley P AnderDepartment of Neurology, University of California at Davis, Sacramento, California, USA.
Sawyer Z BauerDepartment of Neurology, University of California at Davis, Sacramento, California, USA.
Austin LuiDepartment of Neurology, University of California at Davis, Sacramento, California, USA.
Bruce G LyethDepartment of Neurological Surgery, University of California at Davis, Sacramento, California, USA.
DaZhi LiuDepartment of Neurology, University of California at Davis, Sacramento, California, USA.
University of California, Davis · USNeurological Surgery · US

Funding

MicroRNA Therapeutics for Traumatic Brain InjuryR01NS114061 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LIU, DAZHI JEFF · 2020 to 2024
$2.5M
Role of the Src Family Kinases in Traumatic Brain InjuryR01NS089901 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LIU, DA ZHI · 2015 to 2019
$1.7M
NINDS NIH HHS R01 NS089901NINDS NIH HHS R01 NS114061
6 · The paper itself

Abstract

Our previous studies demonstrated that traumatic brain injury (TBI) and ventricular administration of thrombin caused hippocampal neuron loss and cognitive dysfunction via activation of Src family kinases (SFKs). Based on SFK localization in brain, we hypothesized SFK subtypes Fyn and c-Src, as well as SFK downstream molecule Rho-associated protein kinase (ROCK), contribute to cell death and cognitive dysfunction after TBI. We administered nanoparticle wrapped small interfering RNA (siRNA)-Fyn and siRNA-c-Src, or ROCK inhibitor Y-27632 to adult rats subjected to moderate lateral fluid percussion (LFP)-induced TBI. Spatial memory function was assessed from 12 to 16 days, and NeuN stained hippocampal neurons were assessed 16 days after TBI. The combination of siRNA-Fyn and siRNA-c-Src, but neither alone, prevented hippocampal neuron loss and spatial memory deficits after TBI. The ROCK inhibitor Y-27632 also prevented hippocampal neuronal loss and spatial memory deficits after TBI. The data suggest that the combined actions of three kinases (Fyn, c-Src, ROCK) mediate hippocampal neuronal cell death and spatial memory deficits produced by LFP-TBI, and that inhibiting this pathway prevents the TBI-induced cell death and memory deficits.

Indexed as

Brain Injuries, TraumaticSpatial MemoryAnimalsHippocampusNeuronsProto-Oncogene Proteins c-fynRatsRats, Sprague-DawleyFyn protein, ratProto-Oncogene Proteins c-fync-SrcFynROCKsiRNAtraumatic brain injury

Identifiers

PMID35109711
PMCPMC8978569
OpenAlexW4210267563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.