Evidence map›Paper›PMID 35108545›Full record

ArticleCell reports2022

Diversity of satellite glia in sympathetic and sensory ganglia.

Aurelia A Mapps, Michael B Thomsen, Erica Boehm, Haiqing Zhao, Samer Hattar, Rejji Kuruvilla

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Glial cells in neuropathic pain.Physiological reviews · 2026
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  14. Glia of the heart's nervous system.Nature reviews. Neuroscience · 2025
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  19. SARS-CoV-2 reshapes mNAR molecular medicine · 2025
    Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Aurelia A MappsDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, 200 Mudd Hall, Baltimore, MD 21218, USA.
Michael B ThomsenDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, 200 Mudd Hall, Baltimore, MD 21218, USA; Section on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.
Erica BoehmDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, 200 Mudd Hall, Baltimore, MD 21218, USA.
Haiqing ZhaoDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, 200 Mudd Hall, Baltimore, MD 21218, USA.
Samer HattarSection on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.
Rejji KuruvillaDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, 200 Mudd Hall, Baltimore, MD 21218, USA. Electronic address: rkuruvilla@jhu.edu.
Johns Hopkins University · USNational Institute of Mental Health · US

Funding

Section on Light and Circadian RhythmsZIAMH002964 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI HATTAR, SAMER · 2017 to 2025
$24.1M
CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Regulation of the intrinsic melanopsin-based light response in ipRGCsR01EY027202 · NEI · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI RONALD Lane BROWN, Joseph Leffler · 2017 to 2026
$5.3M
Coupled axonal protein synthesis and lipidation in axon growth and homeostasisR01NS114478 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2020 to 2024
$2.2M
The Role of CFAP69 in OlfactionR01DC016065 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI ZHAO, HAIQING · 2018 to 2022
$2.0M
Neurotrophin mechanisms in neural development and diseaseR01NS073751 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2011 to 2015
$1.7M
Neurotrophic factor trafficking and signaling in development and diseaseR01NS107342 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2019 to 2022
$1.7M
Intramural NIH HHS ZIA MH002964NEI NIH HHS R01 EY027202NIDCD NIH HHS R01 DC016065NIGMS NIH HHS T32 GM007231NINDS NIH HHS R01 NS073751NINDS NIH HHS R01 NS107342NINDS NIH HHS R01 NS114478
6 · The paper itself

Abstract

Satellite glia are the major glial type found in sympathetic and sensory ganglia in the peripheral nervous system, and specifically, contact neuronal cell bodies. Sympathetic and sensory neurons differ in morphological, molecular, and electrophysiological properties. However, the molecular diversity of the associated satellite glial cells remains unclear. Here, using single-cell RNA sequencing analysis, we identify five different populations of satellite glia from sympathetic and sensory ganglia. We define three shared populations of satellite glia enriched in immune-response genes, immediate-early genes, and ion channels/ECM-interactors, respectively. Sensory- and sympathetic-specific satellite glia are differentially enriched for modulators of lipid synthesis and metabolism. Sensory glia are also specifically enriched for genes involved in glutamate turnover. Furthermore, satellite glia and Schwann cells can be distinguished by unique transcriptional signatures. This study reveals the remarkable heterogeneity of satellite glia in the peripheral nervous system.

Indexed as

AnimalsGanglia, SensoryGanglia, SpinalGanglia, SympatheticHumansMiceNeurogliaNeuronsNeurons, AfferentPeripheral Nervous SystemSchwann Cellsmolecular diversityperipheral nervous systemsatellite gliasensory gangliasympathetic gangliatranscriptional atlas

Identifiers

PMID35108545
PMCPMC8842985
OpenAlexW4226401865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.