ArticleCell reports2022
Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A.
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80 citing papers in PubMed, 115 citations in OpenAlex.
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20 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 3 institutions in 1 country.
Chris S MantsoungaVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Cadence LeeVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Jade NeversonVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Sheila SharmaVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Abigail HealyVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Joshua M BerusVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Crystal ParryVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Nicolle M CeneriVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Francesc López-GiráldezYale Center for Genome Analysis (YCGA), Yale University, Orange, CT 06477, USA.
Hyung J ChunDepartment of Medicine, Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Qing LuVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Frank SellkeVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Cardiovascular Research Center, Lifespan Cardiovascular Research Institute, Rhode Island Hospital, Providence, RI, USA.
Gaurav ChoudharyVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
Alan R MorrisonVascular Research Laboratory, Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA; Ocean State Research Institute, Inc., Providence, RI 02908, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA. Electronic address: alan_morrison@brown.edu.
Providence College · USYale Cancer Center · USYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MUncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O, MANTSOUNGA, CHRIS S · 2013 to 2022
$21.3MU-RISE at University of Maryland Baltimore CountyT34GM136497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PHYLLIS R ROBINSON · 2020 to 2026
$9.5MEffect of Cardioplegia and Cardiopulmonary Bypass on Coronary Microvascular ReactivityR01HL046716 · NHLBI · RHODE ISLAND HOSPITAL · PI SELLKE, FRANK W · 1997 to 2023
$8.5MVascular Dysfunction in Myocardial Ischemia and Metabolic SyndromeR01HL128831 · NHLBI · RHODE ISLAND HOSPITAL · PI SELLKE, FRANK W, USHEVA-SIMIDJIYSKA, ANNY · 2016 to 2025
$5.7MCenter for Cancer Signaling NetworksP30GM103410 · NIGMS · BROWN UNIVERSITY · PI ATWOOD, WALTER J · 2012 to 2015
$4.3MRole of Endothelial Regulation of Fatty Acid Uptake in Metabolic DysfunctionR01HL142818 · NHLBI · YALE UNIVERSITY · PI CHUN, HYUNG JOON, HWA, JOHN · 2018 to 2021
$2.1MShort-Term Training Program to Increase Diversity in Health-Related ResearchR25HL088992 · NHLBI · BROWN UNIVERSITY · PI ABID, RUHUL, DIAZ, JOSEPH A · 2007 to 2024
$1.9MDevelopment of Rac-Targeted Therapeutic Strategy for Treatment of Calcific AtherosclerosisR01HL139795 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI MORRISON, ALAN ROSS · 2018 to 2022
$1.8MRole of Endothelial Anoctamin-1 in Pulmonary Arterial HypertensionR01HL148727 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV · 2019 to 2022
$1.6MCardiovascular Surgery Research TrainingT32HL160517 · NHLBI · RHODE ISLAND HOSPITAL · PI Frank W Sellke · 2022 to 2026
$1.5MHDAC6 regulates cigarette smoke-induced endothelial barrier dysfunction and lung injuryR01HL130230 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI ROUNDS, SHARON IRENE SMITH · 2016 to 2019
$1.3MBLRD VA IK2 BX002527CSRD VA I01 CX001892CSRD VA I01 CX002231NCATS NIH HHS UL1 TR001863NHLBI NIH HHS F31 HL147466NHLBI NIH HHS R01 HL046716NHLBI NIH HHS R01 HL128831NHLBI NIH HHS R01 HL130230NHLBI NIH HHS R01 HL139795NHLBI NIH HHS R01 HL142818NHLBI NIH HHS R01 HL148727NHLBI NIH HHS R25 HL088992NHLBI NIH HHS T32 HL160517NIGMS NIH HHS P20 GM103652NIGMS NIH HHS P30 GM103410NIGMS NIH HHS T34 GM136497
Abstract
Peripheral artery disease (PAD) leads to considerable morbidity, yet strategies for therapeutic angiogenesis fall short of being impactful. Inflammatory macrophage subsets play an important role in orchestrating post-developmental angiogenesis, but the underlying mechanisms are unclear. Here, we find that macrophage VEGF-A expression is dependent upon the potent inflammatory cytokine, IL-1β. IL-1β promotes pro-angiogenic VEGF-A
Indexed as
AnimalsCytokinesDNA-Binding ProteinsInterleukin-1betaMacrophagesMice, TransgenicNF-kappa BPromoter Regions, GeneticSTAT3 Transcription FactorTrans-ActivatorsVascular Endothelial Growth Factor ACytokinesDNA-Binding ProteinsIL1B protein, mouseInterleukin-1betaNF-kappa BStat3 protein, mouseSTAT3 Transcription FactorTrans-ActivatorsVascular Endothelial Growth Factor Aangiogenesishindlimb ischemiahindlimbinflammationinterleukin-1macrophageNF-κBperipheral artery diseaseSTAT3vascular biologyVEGF-A
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