ArticleCurrent biology : CB2022
Flexible encoding of objects and space in single cells of the dentate gyrus.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Intrinsic Excitability of Rat Hippocampal Granule Cells Increases Along the Dorsal-to-Ventral Axis.Hippocampus · 2026Article
- Sensitive Molecules Involved in Spatial Learning and Memory Impairment of Mice Induced by 4.3 GHz Microwave Radiation.Biomolecules · 2026Article
- The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations.Nature neuroscience · 2026Article
- Altered Physiology and Ensemble Recruitment of Dentate Gyrus Semilunar Granule Cells in a Mouse Model of Epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Landmark vector cells in the absence of visual input.iScience · 2025Article
- Dentate spikes comprise a continuum of relative input strength from the lateral and medial entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks.Function (Oxford, England) · 2025Article
- Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice.Nature communications · 2025Article
- Transient DREADD Manipulation of the Dorsal Dentate Gyrus in Rats Impairs Initial Learning of Place-Outcome Associations.Hippocampus · 2025Article
- Towards an Understanding of the Dentate Gyrus Hilus.Hippocampus · 2025Review
- Between similarity and difference: network dynamics of the hippocampal- parahippocampal circuitry in pattern separation of male Wistar rats.Frontiers in cellular neuroscience · 2025Article
- Vector coding and place coding in hippocampus share a common directional signal.Nature communications · 2024Article
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- Article
- Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease.bioRxiv : the preprint server for biology · 2024Article
- Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Adult Neurogenesis, Context Encoding, and Pattern Separation: A Pathway for Treating Overgeneralization.Advances in neurobiology · 2024Review
- Adult-born granule cells facilitate remapping of spatial and non-spatial representations in the dentate gyrus.Neuron · 2023Article
- Assessments of dentate gyrus function: discoveries and debates.Nature reviews. Neuroscience · 2023Review
Corrections and comments
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7 authors.
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Abstract
The hippocampus is involved in the formation of memories that require associations among stimuli to construct representations of space and the items and events within that space. Neurons in the dentate gyrus (DG), an initial input region of the hippocampus, have robust spatial tuning, but it is unclear how nonspatial information may be integrated with spatial activity in this region. We recorded from the DG of 21 adult mice as they foraged for food in an environment that contained discrete objects. We found DG cells with multiple firing fields at a fixed distance and direction from objects (landmark vector cells) and cells that exhibited localized changes in spatial firing when objects in the environment were manipulated. By classifying recorded DG cells into putative dentate granule cells and mossy cells, we examined how the addition or displacement of objects affected the spatial firing of these DG cell types. Object-related activity was detected in a significant proportion of mossy cells. Although few granule cells with responses to object manipulations were recorded, likely because of the sparse nature of granule cell firing, there was generally no significant difference in the proportion of granule cells and mossy cells with object responses. When mice explored a second environment with the same objects, DG spatial maps completely reorganized, and a different subset of cells responded to object manipulations. Together, these data reveal the capacity of DG cells to detect small changes in the environment while preserving a stable spatial representation of the overall context.
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