ArticleCell metabolism2022
Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis.
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Article in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
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Who cites it
45 citing papers in PubMed, 69 citations in OpenAlex.
- Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.Haematologica · 2024Trial
- Rosmarinic acid-cerium nanocatalysts enable oxygenation-enhanced ROS neutralization and PET imaging-guided therapy for acute kidney injury.Bioactive materials · 2027Article
- Association of transglutaminase-2 with contrast-induced acute kidney injury in Chinese patients with acute coronary syndrome: a prospective cohort study.Annals of medicine · 2026Article
- Article
- Comprehensive Profiling of Chemical Constituents in Niaoduqing Granules by Ultra-High-Performance Liquid Chromatography-Q-Exactive Orbitrap Mass Spectrometry and Identification of Potential Renoprotective Active Components.Journal of separation science · 2026Article
- Carnitine dysregulation in diabetic kidney disease: from pathogenic mechanism to precision biomarker.Journal of translational medicine · 2026Review
- Inosine promotes erythrocyte metabolic reprogramming and restores oxygen release for rejuvenation via 2,3-BPG-PNP axis.Cell discovery · 2026Article
- Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance.Cell genomics · 2026Article
- Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude.Cell metabolism · 2026Article
- Erythropoiesis-inosine metabolic axis failure underlying retinal neurodegeneration in glaucoma: novel diagnoses and therapies.Experimental & molecular medicine · 2026Article
- Transcriptomic landscape of human circular RNAs: unveiling molecular mechanisms in high-altitude adaptation.Frontiers in genetics · 2026Article
- High-Throughput Metabolomics in Transfusion Medicine.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Article
- Metabolic alterations in erythrocytes associated with long-term hypoxia at high altitude.BMC genomics · 2025Article
- Article
- Red blood cell metabolism: a window on systems health towards clinical metabolomics.Current opinion in hematology · 2025Review
- Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation.Journal of translational medicine · 2025Review
- RBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell.PLoS computational biology · 2025Article
- Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment.Frontiers in immunology · 2025Review
- Metabolic insights into hypoxia adaptation in adolescent athletes at different altitudes: a cross-sectional study.Frontiers in molecular biosciences · 2025Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Ping XuDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Changhan ChenDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yujin ZhangDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Benjamin C BrownDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Weiru ZhangDepartment of General Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Tingting XieDepartment of General Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Osheiza AbdulmalikDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Anren SongDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA.
Chao TongDepartment of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Hongbo QiDepartment of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Robert RoachAltitude Research Center, Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Rodney E KellemsDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Yang XiaDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA. Electronic address: yang.xia@uth.tmc.edu.
University of Colorado Denver · USCentral South University · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNChildren's Hospital of Philadelphia · USTexas Medical Center · US
Funding
The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9MThe role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4MInteractions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6MErythrocyte metabolomic profiling reveals new insight and approaches to promote oxygen deliveryR01HL136969 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI PUTKEY, JOHN ANTHONY, ZHANG, YUJIN · 2017 to 2019
$1.5MMolecular insight of erythrocyte hypoxic metabolic reprogramming in chronic kidney diseaseR01HL137990 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2017 to 2018
$989kMIRAGES: Metabolic Investigation of Red blood cells as a function of Aging, Genetics, Environment, and StorageR21HL150032 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2021
$414kNHLBI NIH HHS R01 HL136969NHLBI NIH HHS R01 HL137990NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R21 HL150032
Abstract
Due to lack of nuclei and de novo protein synthesis, post-translational modification (PTM) is imperative for erythrocytes to regulate oxygen (O
Indexed as
CarnitineRenal Insufficiency, ChronicAnimalsErythrocytesHomeostasisHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMiceOxygenSolute Carrier Family 22 Member 5TransglutaminasesCarnitineHypoxia-Inducible Factor 1, alpha SubunitOxygenSLC22A5 protein, humanSolute Carrier Family 22 Member 5Transglutaminasesbisphosphoglycerate mutasechronic kidney diseaseerythrocyteHIF-1αhypoxiaL-carnitinePPARαproteostasisSlc22a5 (OCTN2))transglutaminase 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.