ArticleAmerican journal of obstetrics and gynecology2022
Pregnancy outcomes among women with endometriosis and fibroids: registry linkage study in Massachusetts.
Article in American journal of obstetrics and gynecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Association between endometriosis and adverse reproductive and perinatal outcomes in women undergoing assisted reproductive technology: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- The relationship between hypertensive disorders in pregnancy and endometriosis: a systematic review and meta-analysis.Reproductive health · 2024Pooled it
- Uterine fibroids and hypertensive disorders of pregnancy: Persistence of risk regardless of myomectomy or fibroid location.Pregnancy hypertension · 2026Article
- Association between preeclampsia and eclampsia in Black women with endometriosis: a scoping review.BMC public health · 2026Article
- Towards microbiome-informed strategies for predicting and preventing pregnancy complications.Reproduction & fertility · 2026Review
- Co-occurrence of endometriosis and uterine fibroids: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Polygenic scores for dizygotic twinning: insights into the genetic architecture of female fertility.Journal of assisted reproduction and genetics · 2025Article
- Association between infertility and incident onset of systemic autoimmune rheumatic disease after childbirth: a population-based cohort study.Human reproduction (Oxford, England) · 2025Article
- Endometriosis and Adverse Pregnancy Outcomes: A Nationwide Population-Based Study.Journal of clinical medicine · 2023Article
- Risk of Gestational Diabetes and Pregnancy-Induced Hypertension with a History of Polycystic Ovary Syndrome: A Nationwide Population-Based Cohort Study.Journal of clinical medicine · 2023Article
- Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundEndometriosis and uterine fibroids are common gynecologic conditions associated with a greater risk for infertility. Previous research has suggested that these conditions are associated with adverse pregnancy outcomes, potentially because of increased utilization of fertility treatments.
objectiveOur objective was to investigate whether women with a history of endometriosis or fibroids had a greater risk for adverse pregnancy outcomes and whether this risk varied by infertility history and fertility treatment utilization. STUDY
designDeliveries (2013-2017) recorded in Massachusetts' vital records were linked to assisted reproductive technology data, hospital stays, and all-payer claims database. We identified endometriosis and fibroids diagnoses via the all-payer claims database before index delivery. Adjusted relative risks for pregnancy complications were modeled using generalized estimating equations with a log link and Poisson distribution. The influence of subfertility or infertility and assisted reproductive technology was also investigated.
resultsAmong 91,825 deliveries, 1560 women had endometriosis and 4212 had fibroids. Approximately 30% of women with endometriosis and 26% of women with fibroids experienced subfertility or infertility without utilizing assisted reproductive technology, and 34% of women with endometriosis and 21% of women with fibroids utilized assisted reproductive technology for the index delivery. Women with a history of endometriosis or fibroids were at a greater risk for pregnancy-induced hypertension, preeclampsia, or eclampsia (endometriosis relative risk, 1.17; fibroids relative risk, 1.08), placental abnormalities (endometriosis relative risk, 1.65; fibroids relative risk, 1.38), and cesarean delivery (endometriosis relative risk, 1.22; fibroids relative risk, 1.17) than women with no history of those conditions. Neonates born to women with a history of endometriosis or fibroids were also at a greater risk for preterm birth (endometriosis relative risk, 1.24; fibroids relative risk, 1.17). Associations between fibroids and low birthweight varied by fertility status or assisted reproductive technology (P homogeneity=.01) and were stronger among noninfertile women.
conclusionEndometriosis or fibroids increased the risk for adverse pregnancy outcomes, possibly warranting differential screening or treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.