ReviewPlant biotechnology journal2022
The LONELY GUY gene family: from mosses to wheat, the key to the formation of active cytokinins in plants.
Review in Plant biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- COMPOSITUM 2/ WHEAT FRIZZY PANICLE dosage dependently regulates inflorescence and root architecture in Triticeae cereals.The Plant journal : for cell and molecular biology · 2026Article
- A k-mer-based genome-wide association study approach empowering gene mining in polyploids.Nature genetics · 2026Article
- Cultivar-dependent regulation of cytokinin biosynthesis in wheat: developmental expression of TaIPT genes and hormonal crosstalk during reproductive development.BMC plant biology · 2026Article
- Genome-Wide Analysis and Expression Profiles ofInternational journal of molecular sciences · 2026Article
- Evolutionary Repurposing of Cytokinin Signaling in Plant Development and Symbiosis.Plants (Basel, Switzerland) · 2026Review
- Genome-wide analysis of the B3 family in apple (Malus domestica Borkh.) and functional identification of MdREM19 involvement in salt stress.BMC genomics · 2026Article
- RcLOG7-1 of castor bean plays dual roles in enhancing drought and salt stress tolerance.Plant cell reports · 2025Article
- The C2H2 Zinc-Finger protein ELR1 negatively regulates cytokinin metabolism and signaling pathway in rice.Functional & integrative genomics · 2025Article
- Exploring LOG genes: drivers of prickle evolution in the plant kingdom.Plant molecular biology · 2025Review
- Identification of a natural RcLOG1 allele linked to prickle development in Rose (Rosa spp.).Planta · 2025Article
- Validated reference genes for normalization of RT-qPCR in developing organs of wheat to study developmentally/spatio-temporally expressed family genes.Scientific reports · 2025Article
- Effects of Varying Nitrogen Concentrations on the Locule Number in Tomato Fruit.Plants (Basel, Switzerland) · 2025Article
- Distinct gene reprogramming in rosetted and symptomless shoots from the same mature rose plants infected with rose rosette virus.Frontiers in plant science · 2025Article
- Article
- Biochemical characterization of a unique cytokinin and nucleotide phosphoribohydrolase Lonely Guy protein fromBiochemistry and biophysics reports · 2024Article
- Cytokinin and ALOG proteins regulate pluripotent stem cell identity in the mossScience advances · 2024Article
- Convergent evolution of plant prickles by repeated gene co-option over deep time.Science (New York, N.Y.) · 2024Article
- Article
- Phytohormone profiling in an evolutionary framework.Nature communications · 2024Article
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LONELY GUY (LOG) was first identified in a screen of rice mutants with defects in meristem maintenance. In plants, LOG codes for cytokinin riboside 5'-monophosphate phosphoribohydrolase, which converts inactive cytokinin nucleotides directly to the active free bases. Many enzymes with the PGGxGTxxE motif have been misannotated as lysine decarboxylases; conversely not all enzymes containing this motif are cytokinin-specific LOGs. As LOG mutants clearly impact yield in rice, we investigated the LOG gene family in bread wheat. By interrogating the wheat (Triticum aestivum) genome database, we show that wheat has multiple LOGs. The close alignment of TaLOG1, TaLOG2 and TaLOG6 with the X-ray structures of two functional Arabidopsis thaliana LOGs allows us to infer that the wheat LOGs 1-11 are functional LOGs. Using RNA-seq data sets, we assessed TaLOG expression across 70 tissue types, their responses to various stressors, the pattern of cis-regulatory elements (CREs) and intron/exon patterns. TaLOG gene family members are expressed variously across tissue types. When the TaLOG CREs are compared with those of the cytokinin dehydrogenases (CKX) and glucosyltransferases (CGT), there is close alignment of CREs between TaLOGs and TaCKXs reflecting the key role of CKX in maintaining cytokinin homeostasis. However, we suggest that the main homeostatic mechanism controlling cytokinin levels in response to biotic and abiotic challenge resides in the CGTs, rather than LOG or CKX. However, LOG transgenics and identified mutants in rice variously impact yield, providing interesting avenues for investigation in wheat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.