Evidence map›Paper›PMID 35108129›Full record

ArticleBrain injury2022

Clinical features of dementia cases ascertained by ICD coding in LIMBIC-CENC multicenter study of mild traumatic brain injury.

William C Walker, Justin O'Rourke, Elisabeth Anne Wilde, Mary Jo Pugh, Kimbra Kenney, Clara Libby Dismuke-Greer, Zhining Ou, Angela P Presson, J Kent Werner, Jacob Kean and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Brain injury, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

William C WalkerDepartment of Physical Medicine and Rehabilitation (PM&R), School of Medicine, Virginia Commonwealth University, and Central Virginia VA Healthcare System, Richmond, Virginia, USA.
Justin O'RourkeTraumatic Brain Injury Model Systems, Polytrauma Rehabilitation Center, South Texas Veterans Healthcare System, San Antonio, Texas, USA.
Elisabeth Anne WildeVA Salt Lake City Health Care System, Department of Neurology, Traumatic Brain Injury and Concussion Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Mary Jo PughVA Salt Lake City Health Care System, Department of Medicine, IDEAS Center of Innovation, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Kimbra KenneyDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Clara Libby Dismuke-GreerHealth Economics Resource Center (HERC), Ci2i, VA Palo Alto Health Care System, Menlo Park, California, USA.
Zhining OuDivision of Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah Hospital, Salt Lake City, Utah, USA.
Angela P PressonDivision of Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah Hospital, Salt Lake City, Utah, USA.
J Kent WernerDepartment of Neurology, School of Medicine, Uniformed Services University, Bethesda, Maryland, USA.
Jacob KeanDepartment of Population Health Sciences, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Deborah BarnesDepartments of Psychiatry and Behavioral Sciences and Epidemiology & Biostatistics, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Amol KarmarkarDepartment of Physical Medicine and Rehabilitation (PM&R), School of Medicine, Virginia Commonwealth University, and Central Virginia VA Healthcare System, Richmond, Virginia, USA.
Kristine YaffeDepartments of Psychiatry and Behavioral Science, Neurology, and Epidemiology & Biostatistics, University of California, San Francisco, California, USA.
David CifuDepartment of Physical Medicine and Rehabilitation (PM&R), School of Medicine, Virginia Commonwealth University, and Central Virginia VA Healthcare System, Richmond, Virginia, USA.

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Chronic Effects of Neurotrauma Consortium (CENC) Epidemiology StudyI01CX001246 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI YAFFE, KRISTINE · 2015 to 2017
–
VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Epidemiology StudyI01CX002096 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Kristine Yaffe · 2020 to 2026
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VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC)I01CX002097 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI DAVID X. CIFU, Rudolph c Johnson · 2021 to 2026
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VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Health Economics StudyI01HX003155 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI DISMUKE, CLARA E · 2022 to 2022
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CENC - Otolith Dysfunction and Postural StabilityI01RX001135 · VA · JAMES H QUILLEN VA MEDICAL CENTER · PI AKIN, FAITH WURM, HALL, COURTNEY · 2015 to 2017
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CENC - Tau Conformation and Phosphorylation in mTBII01RX001774 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI CRAWFORD, FIONA C. · 2015 to 2018
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CENC - Diffusion Tensor Imaging Standardization using Novel MR Diffusion PhantomsI01RX001880 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI WILDE, ELISABETH A · 2015 to 2020
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CENC - Novel White Matter Imaging to Improve Diagnosis of Mild TBII01RX002076 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI JAK, AMY · 2015 to 2018
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CENC- Longitudinal Cohort StudyI01CX001135 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI BELANGER, HEATHER G, CIFU, DAVID X. · 2015 to 2019
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CENC - Clinical and Neuroimaging Correlates of Neurodegeneration in Military mTBII01RX002171 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI DAVENPORT, NICHOLAS DAVID · 2016 to 2019
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CENC - Structural and Functional Neurobiology of Veterans Exposed to Primary Blast ForcesI01RX002172 · VA · W G HEFNER VA MEDICAL CENTER · PI TABER, KATHERINE H · 2016 to 2019
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CSRD VA I01 CX001135CSRD VA I01 CX001246CSRD VA I01 CX002096CSRD VA I01 CX002097HSRD VA I01 HX003155NCATS NIH HHS UL1 TR002538RRD VA I01 RX001135RRD VA I01 RX001774RRD VA I01 RX001880RRD VA I01 RX002076RRD VA I01 RX002170RRD VA I01 RX002171RRD VA I01 RX002172RRD VA I01 RX002173RRD VA I01 RX002174RRD VA I01 RX003442RRD VA I01 RX003443RRD VA I01 RX003444
6 · The paper itself

Abstract

objectiveDescribe dementia cases identified through International Classification of Diseases (ICD) coding in the Long-term Impact of Military-relevant Brain Injury Consortium - Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) multicenter prospective longitudinal study (PLS) of mild traumatic brain injury (mTBI).

designDescriptive case series using cross-sectional data.

methodsVeterans Affairs (VA) health system data including ICD codes were obtained for 1563 PLS participants through the VA Informatics and Computing Infrastructure (VINCI). Demographic, injury, and clinical characteristics of Dementia positive and negative cases are described.

resultsFive cases of dementia were identified, all under 65 years old. The dementia cases all had a history of blast-related mTBI and all had self-reported functional problems and four had PTSD symptomatology at the clinical disorder range. Cognitive testing revealed some deficits especially in the visual memory and verbal learning and memory domains, and that two of the cases might be false positives.

conclusionsICD codes for early dementia in the VA system have specificity concerns, but could be indicative of cognitive performance and self-reported cognitive function. Further research is needed to better determine links to blast exposure, blast-related mTBI, and PTSD to early dementia in the military population.

Indexed as

Blast InjuriesBrain ConcussionDementiaStress Disorders, Post-TraumaticVeteransAfghan Campaign 2001-AgedCross-Sectional StudiesHumansInternational Classification of DiseasesIraq War, 2003-2011Longitudinal StudiesProspective StudiescognitionconcussiondementiamilitaryTraumatic brain injuryveteran

Identifiers

PMID35108129
PMCPMC9187581

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.