ArticleApplied and environmental microbiology2022
Characterization of GefA, a GGEEF Domain-Containing Protein That Modulates Vibrio parahaemolyticus Motility, Biofilm Formation, and Virulence.
Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The transcription factor LafI integrates control of flagellar motility and T3SS1-mediated virulence inApplied and environmental microbiology · 2026Article
- Strain-level heterogeneity in Vibrio parahaemolyticus limits the predictive value of baseline planktonic gene expression for surface-associated phenotypes.Scientific reports · 2026Article
- T3SS1 accessory protein geneFrontiers in cellular and infection microbiology · 2026Article
- AphA-dependent c-di-GMP production inJournal of bacteriology · 2025Article
- CalR is an activator of biofilm formation inApplied and environmental microbiology · 2025Article
- Investigating c-di-GMP Signaling in Vibrio parahaemolyticus: Biological Effects and Mechanisms of Regulation.Current microbiology · 2025Review
- Sublethal Curcumin Exposure Induces Global Gene Expression and Biofilm-Related Phenotypic Changes in Vibrio parahaemolyticus.Current microbiology · 2025Article
- The Two-Component System TtrRS Regulates the Expression of the 05890-05900 Operon that Promotes the Sulfur Metabolism of Vibrio parahaemolyticus.Current microbiology · 2025Article
- H-NS represses fliD transcription for lateral flagellar filament cap in Vibrio parahaemolyticus.Archives of microbiology · 2025Article
- The coordinated regulatory impact of AcsS and TpdA on biofilm formation inFrontiers in microbiology · 2025Article
- The LuxO-OpaR quorum-sensing cascade differentially controls Vibriophage VP882 lysis-lysogeny decision making in liquid and on surfaces.PLoS genetics · 2024Article
- IcmF2 of the type VI secretion system 2 plays a role in biofilm formation of Vibrio parahaemolyticus.Archives of microbiology · 2024Article
- Environmental magnesium ion affects global gene expression, motility, biofilm formation and virulence ofBiofilm · 2024Article
- Evaluation of Therapeutic Efficiency of Stylicin against Vibrio parahaemolyticus Infection in Shrimp Penaeus vannamei through Comparative Proteomic Approach.Probiotics and antimicrobial proteins · 2024Article
- Article
- The effect of environmental calcium on gene expression, biofilm formation and virulence ofFrontiers in microbiology · 2024Article
- Transcriptomic Profiles of Vibrio parahaemolyticus During Biofilm Formation.Current microbiology · 2023Article
- L-arabinose affects the growth, biofilm formation, motility, c-di-GMP metabolism, and global gene expression ofJournal of bacteriology · 2023Article
- Article
- OpaR Exerts a Dynamic Control over c-di-GMP Homeostasis andMicrobiology spectrum · 2023Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio parahaemolyticus is a significant foodborne pathogen that causes economic and public health problems worldwide and has a high capacity to adapt to diverse environments and hosts. The second messenger cyclic diguanylate monophosphate (c-di-GMP) allows bacteria to shift from a planktonic form to a communal multicellular lifestyle and plays an important role in bacterial survival and transmission. Here, we characterized single-domain c-di-GMP synthetases in V. parahaemolyticus and identified a novel GGEEF domain-containing protein designated GefA that modulates bacterial swarming motility, biofilm formation, and virulence. GefA inhibits swarming motility by regulating the expression of lateral flagella, while it enhances biofilm formation by controlling exopolysaccharide biosynthesis. Under high-c-di-GMP conditions caused by
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