Evidence map›Paper›PMID 35108075›Full record

ArticleApplied and environmental microbiology2022

Combining Microscopy Assays of Bacteria-Surface Interactions To Better Evaluate Antimicrobial Polymer Coatings.

M K L N Sikosana, A Ruland, C Werner, L D Renner

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. PreventingACS applied materials & interfaces · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M K L N SikosanaLeibniz Institut für Polymerforschung Dresden eV (IPF), Max Bergmann Center for Biomaterials, Dresden, Germany.
A RulandLeibniz Institut für Polymerforschung Dresden eV (IPF), Max Bergmann Center for Biomaterials, Dresden, Germany.
C WernerLeibniz Institut für Polymerforschung Dresden eV (IPF), Max Bergmann Center for Biomaterials, Dresden, Germany.
L D RennerLeibniz Institut für Polymerforschung Dresden eV (IPF), Max Bergmann Center for Biomaterials, Dresden, Germany.ORCID 0000-0003-0178-1788

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Validation of the antimicrobial performance of contact-killing polymer surfaces through the experimental determination of bacterial adhesion or viability, is essential for their targeted development and application. However, there is not yet a consensus on the single most appropriate evaluation method or procedure. Combining and benchmarking previously reported assays could reduce the significant variation and misinterpretation of efficacy data obtained from different methods. In this work, we systematically investigated the response of bacterial cells to antiadhesive and antiseptic polymer coatings by combining (i) bulk solution-based, (ii) thin-film spacer-based, and (iii) direct-contact assays. In addition, we evaluated the studied assays using a five-point scoring framework that highlights key areas for improvement. Our data suggest that combined microscopy assays provide a more comprehensive representation of antimicrobial performance, thereby helping to identify effective types of antibacterial polymer coatings.

Indexed as

Anti-Infective AgentsPolymersAnti-Bacterial AgentsBacteriaMicroscopySurface PropertiesAnti-Bacterial AgentsAnti-Infective AgentsPolymersantimicrobial surfacesbacterial adhesionbacteria-surface interactionssingle-cell assays

Identifiers

PMID35108075
PMCPMC8939340

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.