Evidence map›Paper›PMID 35108073›Full record

ArticleMolecular biology of the cell2022

Quantification of microtubule stutters: dynamic instability behaviors that are strongly associated with catastrophe.

Shant M Mahserejian, Jared P Scripture, Ava J Mauro, Elizabeth J Lawrence, Erin M Jonasson, Kristopher S Murray, Jun Li, Melissa Gardner, Mark Alber, Marija Zanic and 1 more

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Mechanical coupling coordinates microtubule growth.bioRxiv : the preprint server for biology · 2023
    Article
  7. Article
  8. Beyond the GTP-cap: Elucidating the molecular mechanisms of microtubule catastrophe.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shant M MahserejianDepartment of Applied and Computational Mathematics and Statistics and.
Jared P ScriptureDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Ava J MauroDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Elizabeth J LawrenceDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240.
Erin M JonassonDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Kristopher S MurrayDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Jun LiDepartment of Applied and Computational Mathematics and Statistics and.
Melissa GardnerDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
Mark AlberDepartment of Applied and Computational Mathematics and Statistics and.
Marija ZanicDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240.
Holly V GoodsonDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.

Funding

Integrated Biological Systems Training in OncologyT32CA119925 · NCI · VANDERBILT UNIVERSITY · PI Vivian Gama, William Patrick Tansey · 2008 to 2026
$7.6M
Biophysical Principles of Microtubule DynamicsR35GM119552 · NIGMS · VANDERBILT UNIVERSITY · PI Marija Zanic · 2016 to 2026
$4.4M
NCI NIH HHS T32 CA119925NIGMS NIH HHS R35 GM119552
6 · The paper itself

Abstract

Microtubules (MTs) are cytoskeletal fibers that undergo dynamic instability (DI), a remarkable process involving phases of growth and shortening separated by stochastic transitions called catastrophe and rescue. Dissecting DI mechanism(s) requires first characterizing and quantifying these dynamics, a subjective process that often ignores complexity in MT behavior. We present a

Indexed as

StutteringCytoskeletonHumansMicrotubulesTubulinTubulin

Identifiers

PMID35108073
PMCPMC9250389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.