ArticleScience translational medicine2022
NF-κB perturbation reveals unique immunomodulatory functions in Prx1
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Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51citing papers in PubMed
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51 citing papers in PubMed, 71 citations in OpenAlex.
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- Antisense molecules: A promising new therapy for atopic dermatitis.Acta pharmaceutica Sinica. B · 2025Review
- A basophil-fibroblast pro-inflammatory axis fuels type 2 skin inflammation.Cell reports · 2025Article
- Uncovering an antifibrotic Prrx1-lineage mesenchymal cell subpopulation in fibrotic lungs.Disease models & mechanisms · 2025Article
- A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders.Human genomics · 2025Article
- Synthetic peptides targeting a mast cell-specific G protein-coupled receptor MRGPRB2 display anti-infective potential.Cell biomaterials · 2025Article
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Authors and funding
19 authors at 5 institutions in 2 countries.
Kang I KoDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2967-8846
Jean J MerletBredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee Knoxville, Knoxville, TN 37996, USA.ORCID 0000-0003-2890-9729
Brett P DerGarabedianDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Huang ZhenDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5591-7340
Yoko Suzuki-HoriuchiDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-3800-6160
Matthew L HedbergDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2810-9724
Eileen HuDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2181-8149
Anh T NguyenDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7272-1171
Stephen ProutyDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9436-8268
Faizan AlawiDepartment of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Matthew C WalshDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yongwon ChoiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sarah E MillarBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-8792-6890
Ashley CliffBredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee Knoxville, Knoxville, TN 37996, USA.ORCID 0000-0001-7809-5546
Jonathon RomeroBredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee Knoxville, Knoxville, TN 37996, USA.ORCID 0000-0001-5249-1946
Michael R GarvinBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA.ORCID 0000-0002-2204-7569
John T SeykoraDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-0383-031X
Daniel JacobsonBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA.ORCID 0000-0002-9822-8251
Dana T GravesDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-4664-8529
University of Pennsylvania · USUniversity of Tennessee at Knoxville · USOak Ridge National Laboratory · USIcahn School of Medicine at Mount Sinai · USKing University · US
Funding
Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0MStudy Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6MSkin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2MMechanisms for Impaired Diabetic Wound HealingR01DE019108 · NIDCR · UNIV OF MED/DENT OF NJ-NJ DENTAL SCHOOL · PI DANA T GRAVES · 2009 to 2026
$4.8MGene Network Identification and Integration (GNetii) Approach to Understanding the Biology Underlying HIV and Drug Abuse.R01DA051908 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JACOBSON, DANIEL A, JOHNSON, ERIC OTTO · 2020 to 2024
$3.4MUnderstanding molecular mechanisms underlying the formation of the blue nevus andP30AR057217 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI COTSARELIS, GEORGE · 2009 to 2013
$3.2MWound healing mechanisms by distinct oral fibroblast populationR01DE030415 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KO, KANG I · 2021 to 2025
$1.9MMechanisms regulating the early stages of UV-induced skin cancerR01ES028114 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI SEYKORA, JOHN T. · 2018 to 2022
$1.8MThe role of NF-kB in mesenchymal stem cells during diabetic wound healingK08DE027129 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KO, KANG I · 2017 to 2021
$521kNIAMS NIH HHS P30 AR057217NIAMS NIH HHS P30 AR069589NIAMS NIH HHS P30 AR079200NIAMS NIH HHS T32 AR007465NIDA NIH HHS R01 DA051908NIDCR NIH HHS K08 DE027129NIDCR NIH HHS R01 DE019108NIDCR NIH HHS R01 DE030415NIEHS NIH HHS R01 ES028114
Abstract
Skin is composed of diverse cell populations that cooperatively maintain homeostasis. Up-regulation of the nuclear factor κB (NF-κB) pathway may lead to the development of chronic inflammatory disorders of the skin, but its role during the early events remains unclear. Through analysis of single-cell RNA sequencing data via iterative random forest leave one out prediction, an explainable artificial intelligence method, we identified an immunoregulatory role for a unique paired related homeobox-1 (Prx1)
Indexed as
Dermatitis, AtopicAnimalsArtificial IntelligenceFibroblastsImmunityMiceNF-kappa BSkinNF-kappa B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.