ArticleJournal of the American Chemical Society2022
Empirical Guidelines for the Development of Remote Directing Templates through Quantitative and Experimental Analyses.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A unified strategy for remote C-H fluorination of phenylacetic acids and their homologues at theChemical science · 2026Article
- Pd-catalyzed sequential distal C-H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams.Chemical science · 2026Article
- Iridium catalyzed regiodivergent functionalization of all three C-H bonds of arenes by a single ligand.Nature communications · 2025Article
- Photochromic Oxime Directing Groups for Spatially Controlled Pd-Catalyzed C-H Difunctionalization with Tandem Electrophiles.ACS catalysis · 2025Article
- Diversity-Oriented C-H Activation Reactions of the Naphthalene Scaffold.Journal of the American Chemical Society · 2025Article
- Three distinct strategies lead to programmable aliphatic C-H oxidation in bicyclomycin biosynthesis.Nature communications · 2025Article
- Rapid and scalable ruthenium catalyzed meta-C-H alkylation enabled by resonant acoustic mixing.Communications chemistry · 2024Article
- Ligand-Controlled NondirectedACS catalysis · 2024Article
- Repurposing a supramolecular iridium catalystChemical science · 2024Article
- Palladium (II)-Catalyzed C-H Activation with Bifunctional Ligands: From Curiosity to Industrialization.Angewandte Chemie (International ed. in English) · 2024Review
- Late-stage meta-C-H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step.Nature communications · 2024Article
- MacrocyclizationChemical science · 2023Article
- Design principles of the use of alkynes in radical cascades.Nature reviews. Chemistry · 2023Review
- Biocatalytic control of site-selectivity and chain length-selectivity in radical amino acid halogenases.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ni-catalyzed benzylic β-C(spNature communications · 2022Article
- Photo-Induced Ruthenium-Catalyzed Double Remote C(spAngewandte Chemie (International ed. in English) · 2022Article
- Pd(ii)-catalyzedChemical science · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
The ability to differentiate and selectively activate remote C-H bonds represents a perennial challenge in the field of C-H activation. Since its first report in 2012, a now-established "directing template" (DT) approach remains demonstrably effective for the functionalization of remote C-H bonds. As selectivity is hypothesized to be principally determined by the optimal positioning of the reactive catalyst to a target C-H bond, a DT's spatial factors are particularly important toward achieving high selectivity, though a systematic study on its requisite factors remain unelucidated. Through an in-depth analysis of 119 structurally unique published remote DTs, this report summarizes the key factors that are central toward achieving high selectivity at defined aryl positions, which are experimentally corroborated through the development of new aliphatic meta and para-selective DTs for electronically unbiased arenes. These empirical rules, which summarize key distance and geometric factors, are expected to be useful tools for the future development of site-selective arene C-H activation as well as other reactions that rely on covalent/noncovalent DT-mediated remote regioselection.
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