Evidence map›Paper›PMID 35107783›Full record

ArticleWorld journal of pediatrics : WJP2022

Urinary cystatin C: pediatric reference intervals and comparative assessment as a biomarker of renal injury among children in the regions with high burden of CKDu in Sri Lanka.

Patabandi Maddumage Mihiri Ayesha Sandamini, Pallage Mangala Chathura Surendra De Silva, Thibbotuwa Deniya Kankanamge Sameera Chathuranga Gunasekara, Sakuntha Dewaka Gunarathna, Ranawake Arachchige Isini Pinipa, Chula Herath, Sudheera Sammanthi Jayasinghe, Ediriweera Patabandi Saman Chandana, Nishad Jayasundara

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In one paragraph

Article in World journal of pediatrics : WJP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Patabandi Maddumage Mihiri Ayesha SandaminiDepartment of Zoology, Faculty of Science, University of Ruhuna, Matara, 81000, Sri Lanka.
Pallage Mangala Chathura Surendra De SilvaDepartment of Zoology, Faculty of Science, University of Ruhuna, Matara, 81000, Sri Lanka. chathura@zoo.ruh.ac.lk.ORCID 0000-0002-1927-6512
Thibbotuwa Deniya Kankanamge Sameera Chathuranga GunasekaraDepartment of Zoology, Faculty of Science, University of Ruhuna, Matara, 81000, Sri Lanka.
Sakuntha Dewaka GunarathnaDepartment of Zoology, Faculty of Science, University of Ruhuna, Matara, 81000, Sri Lanka.
Ranawake Arachchige Isini PinipaDepartment of Zoology, Faculty of Science, University of Ruhuna, Matara, 81000, Sri Lanka.
Chula HerathDepartment of Nephrology, Sri Jayewardenepura General Hospital, Colombo, 10100, Sri Lanka.
Sudheera Sammanthi JayasingheDepartment of Pharmacology, Faculty of Medicine, University of Ruhuna, Galle, 80000, Sri Lanka.
Ediriweera Patabandi Saman ChandanaDepartment of Biosystems Technology, Faculty of Technology, University of Ruhuna, Matara, 81000, Sri Lanka.
Nishad JayasundaraThe Nicholas School of the Environment, Duke University, Durham, NC, 27708, USA.
University of Ruhuna · LKDuke University · USUniversity of Sri Jayewardenepura · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCystatin C (Cys-C) is an emerging biomarker of renal diseases and its clinical use, particularly for screening the communities affected by chronic kidney disease of unknown etiology (CKDu), is hindered due to the lack of reference intervals (RIs) for diverse ethnic and age groups. The present study aimed to define RIs for urinary Cys-C (uCys-C) for a healthy pediatric population in Sri Lanka and in turn compare the renal function of the residential children in CKDu endemic and non-endemic regions in Sri Lanka.

methodsA cross-sectional study was conducted with 850 healthy children (10-17 years) from selected locations for reference interval establishment, while a total of 892 children were recruited for the comparative study. Urine samples were collected and analyzed for Cys-C, creatinine (Cr) and albumin. Cr-adjusted uCys-C levels were partitioned by age, and RIs were determined with quantile regression (2.5th, 50th and 97.5th quantiles) at 90% confidence interval.

resultsThe range of median RIs for uCys-C in healthy children was 45.94-64.44 ng/mg Cr for boys and 53.58-69.97 ng/mg Cr for girls. The median (interquartile range) uCys-C levels of children in the CKDu endemic and non-endemic regions were 58.18 (21.8-141.9) and 58.31 (23.9-155.3) ng/mg Cr with no significant difference (P = 0.781). A significant variation of uCys-C was noted in the children across age.

conclusionsNotably high uCys-C levels were observed in children with elevated proteinuria. Thus, uCys-C could be a potential biomarker in identifying communities at high risk of CKDu susceptibility.

Indexed as

Cystatin CRenal Insufficiency, ChronicAdolescentBiomarkersChildCreatinineCross-Sectional StudiesFemaleHumansKidneyMaleSri LankaBiomarkersCreatinineCystatin CChronic kidney disease of unknown etiologyCystatin CPediatricReference intervalsRenal injuryUrinary albumin–creatinine ratio

Identifiers

PMID35107783
OpenAlexW4210660429

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.