Evidence map›Paper›PMID 35107739›Full record

ArticleMolecular biology reports2022

The influence of gastric bypass surgery on the concentration of high mobility group box 1, nuclear factor erythroid 2-related factor 2 and the genes expression of high mobility group box 1, nuclear factor erythroid2-related factor 2, interleukin 6, and tumor necrosis factor-alpha in the peripheral blood mononuclear cells of patients with morbid obesity.

Masouod Khanaghaei, Nasrin Ziamajidi, Jalal Poorolajal, Gholamreza Asadikaram, Payam Nikoyan, Mohammadhosein Bajian, Roghayeh Abbasalipourkabir

Abstract read
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In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Masouod KhanaghaeiDepartment of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Nasrin ZiamajidiDepartment of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Jalal PoorolajalDepartment of Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Gholamreza AsadikaramDepartment of Biochemistry and Nutrition, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Payam NikoyanKerman Mehregan Bariatric Surgery Center, Kerman University of Medical Sciences, Kerman, Iran.
Mohammadhosein BajianKerman Mehregan Bariatric Surgery Center, Kerman University of Medical Sciences, Kerman, Iran.
Roghayeh AbbasalipourkabirDepartment of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. rpourkabir@hotmail.com.ORCID http://orcid.org/0000-0002-6345-1410
Hamedan University of Medical Sciences · IRKerman University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesObesity is known as a disease with a chronic low-grade state of inflammation and high levels of oxidative stress. Given the challenges and consequences caused by obesity, obesity therapy is an essential subject to address. For sustainable weight loss, gastric bypass surgery is the most successful and essential option.

methodsThis prospective cohort study was performed on 35 patients aged (18-54) with morbid obesity (BMI: 42.06 kg/m

resultsFour months following surgery, the BMI, hip and waist circumferences, and waist-to-hip ratio (WHR) all decreased significantly. The lipid profile and antioxidant power were dramatically enhanced after surgery. IL-6 and TNF-α expression in PBMC patients showed a significant decrease after surgery. HMGB1 and Nrf2 expression in PBMC of postoperative patients decreased compared to before surgery, and HMGB1, and Nrf2 protein levels also decreased after surgery.

conclusionWeight loss indicated the significant function of adipose tissue in the induction of oxidative stress and inflammatory factors. Gastric bypass reduced the inflammation conditions and improved the metabolic status and living situations in the patients with morbid obesity.

Indexed as

Gastric BypassHMGB1 ProteinNF-E2-Related Factor 2Obesity, MorbidHumansInflammationInterleukin-6Leukocytes, MononuclearProspective StudiesTumor Necrosis Factor-alphaWeight LossHMGB1 ProteinHMGB1 protein, humanInterleukin-6NFE2L2 protein, humanNF-E2-Related Factor 2Tumor Necrosis Factor-alphaHigh mobility group box 1Morbid obesityNuclear factor erythroid2–related factor 2Oxidative stressSurgery

Identifiers

PMID35107739
OpenAlexW4210422882

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.