Evidence map›Paper›PMID 35107724›Full record

ArticleCancer causes & control : CCC2022

Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study: research methods and cohort profile.

Marilyn L Kwan, Diana L Miglioretti, Erin J A Bowles, Sheila Weinmann, Robert T Greenlee, Natasha K Stout, Alanna Kulchak Rahm, Susan A Alber, Priscila Pequeno, Lisa M Moy and 21 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 12 institutions in 3 countries.

Marilyn L Kwan *Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA. Marilyn.L.Kwan@kp.org.ORCID http://orcid.org/0000-0001-8863-3950
Diana L Miglioretti *Department of Public Health Sciences, University of California, Davis, CA, USA.
Erin J A BowlesKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
Sheila WeinmannCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Robert T GreenleeMarshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA.
Natasha K StoutDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Alanna Kulchak RahmCenter for Health Research, Genomic Medicine Institute, Geisinger, Danville, PA, USA.
Susan A AlberDepartment of Public Health Sciences, University of California, Davis, CA, USA.
Priscila PequenoICES, Toronto, ON, Canada.
Lisa M MoyDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA.
Carly StewartDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Cindy FongICES, Toronto, ON, Canada.
Charisma L JenkinsCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Diane KohnhorstMarshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA.
Casey LuceKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
Joanne M MorCenter for Integrated Health Research, Kaiser Permanente Hawaii, Honolulu, HI, USA.
Julie R MunnekeDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA.
Yolanda PradoCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Glen ButhMarshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA.
Stephanie Y ChengICES, Toronto, ON, Canada.
Kamala A DeosaransinghDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA.
Melanie FranciscoCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Matthew LakomaDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Yannica Theda MartinezCenter for Integrated Health Research, Kaiser Permanente Hawaii, Honolulu, HI, USA.
Mary Kay TheisKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
Emily C MarlowDepartment of Public Health Sciences, University of California, Davis, CA, USA.
Lawrence H KushiDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA.
James R DuncanInterventional Radiology Section, Washington University in St. Louis, St. Louis, MI, USA.
Wesley E BolchJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Jason D PoleICES, Toronto, ON, Canada.
Rebecca Smith-BindmanDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Kaiser Permanente · USKaiser Permanente Washington Health Research Institute · USKaiser Permanente Center for Health Research · USMarshfield Clinic · USHarvard University · USUniversity of California, Davis · USGeisinger Health System · USLee University · USThe University of Queensland · AUUniversity of California, San Francisco · USUniversity of Florida · USWashington University in St. Louis · US

Funding

Risk of Pediatric and Adolescent Cancer Associated with Medical ImagingR01CA185687 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KWAN, MARILYN L, MIGLIORETTI, DIANA L · 2015 to 2019
$10.0M
Group Health Cancer Research Program Research Specialist AwardR50CA211115 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI BOWLES, ERIN JANELLE AIELLO · 2017 to 2021
$919k
NCI NIH HHS R01 CA185687NCI NIH HHS R01CA185687NCI NIH HHS R50 CA211115NCI NIH HHS R50CA211115
6 · The paper itself

Abstract

purposeThe Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study is quantifying the association between cumulative radiation exposure from fetal and/or childhood medical imaging and subsequent cancer risk. This manuscript describes the study cohorts and research methods.

methodsThe RIC Study is a longitudinal study of children in two retrospective cohorts from 6 U.S. healthcare systems and from Ontario, Canada over the period 1995-2017. The fetal-exposure cohort includes children whose mothers were enrolled in the healthcare system during their entire pregnancy and followed to age 20. The childhood-exposure cohort includes children born into the system and followed while continuously enrolled. Imaging utilization was determined using administrative data. Computed tomography (CT) parameters were collected to estimate individualized patient organ dosimetry. Organ dose libraries for average exposures were constructed for radiography, fluoroscopy, and angiography, while diagnostic radiopharmaceutical biokinetic models were applied to estimate organ doses received in nuclear medicine procedures. Cancers were ascertained from local and state/provincial cancer registry linkages.

resultsThe fetal-exposure cohort includes 3,474,000 children among whom 6,606 cancers (2394 leukemias) were diagnosed over 37,659,582 person-years; 0.5% had in utero exposure to CT, 4.0% radiography, 0.5% fluoroscopy, 0.04% angiography, 0.2% nuclear medicine. The childhood-exposure cohort includes 3,724,632 children in whom 6,358 cancers (2,372 leukemias) were diagnosed over 36,190,027 person-years; 5.9% were exposed to CT, 61.1% radiography, 6.0% fluoroscopy, 0.4% angiography, 1.5% nuclear medicine.

conclusionThe RIC Study is poised to be the largest study addressing risk of childhood and adolescent cancer associated with ionizing radiation from medical imaging, estimated with individualized patient organ dosimetry.

Indexed as

LeukemiaAdolescentAdultChildFemaleHumansLongitudinal StudiesOntarioPregnancyRadiographyRetrospective StudiesYoung AdultChildhood cancerChildhood leukemiaComputed tomographyIonizing radiationMedical imagingRetrospective cohort study

Identifiers

PMID35107724
PMCPMC9596345
OpenAlexW4210615343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.