Evidence map›Paper›PMID 35107691›Full record

ArticleVirus genes2022

A virus like particle approach to study the Chikungunya virus envelope protein mutations.

Asha Maria Mathew, B Anukumar

Abstract read
PubMed Publisher
In one paragraph

Article in Virus genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Asha Maria Mathew *ICMR-National Institute of Virology, Kerala Unit, Govt. TDMC Hospital Complex, Vandanam, Alappuzha, Kerala, 688005, India.
B Anukumar *ICMR-National Institute of Virology, Kerala Unit, Govt. TDMC Hospital Complex, Vandanam, Alappuzha, Kerala, 688005, India. anukumar74@gmail.com.ORCID http://orcid.org/0000-0002-2958-4391
ICMR-National Institute of Virology · INT. D. Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus like particles (VLPs) are used as a tool to study the mutations in the structural genes that influence the virus assembly and entry process. We observed that Chikungunya VLP with the E1:V291I mutation produced more fluorescence-positive cells in Vero cells than the other mutant VLPs (E1:A226V, D284E, and E2:V264A) and wild-type VLP tested in this study. According to the findings, the V291I mutation may aid the virus's ability to enter the cells more efficiently than wild-type VLPs. The study concludes that VLP is a useful model for studying the virus entry process in cells.

Indexed as

Chikungunya FeverAnimalsChlorocebus aethiopsMutationVero CellsViral Envelope ProteinsVirus AssemblyViral Envelope ProteinsChikungunya virusReplicationSite directed mutationVirus entryVirus like particles

Identifiers

PMID35107691
OpenAlexW4210449039

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.