Evidence map›Paper›PMID 35107601›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials.

Pedro Machado, Miguel Morgado, João Raposo, Marco Mendes, Cândida G Silva, Nuno Morais

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Trial
  8. Trial
  9. Review
  10. Observational
  11. Acute cancer-related fatigue response following exercise during an outpatient cancer rehabilitation program.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational
  12. The relationship between the latent profiles of cancer-related fatigue characteristics and exercise adherence in colorectal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  13. Review
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  15. Article
  16. Review
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  18. Article
  19. A qualitative exploration of exercise motivation among colorectal cancer survivors: an application of the theory of planned behavior.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  20. Relationships Among Physical Activity, Sleep, and Cancer-related Fatigue: Results From the International ColoCare Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pedro MachadoCenter for Innovative Care and Health Technology (ciTechCare), Polytechnic of Leiria, Leiria, Portugal. pedro.machado@ipleiria.pt.ORCID http://orcid.org/0000-0003-1147-2778
Miguel MorgadoSchool of Health Sciences (ESSLei), Polytechnic of Leiria, Leiria, Portugal.ORCID http://orcid.org/0000-0001-6478-8886
João RaposoSchool of Health Sciences (ESSLei), Polytechnic of Leiria, Leiria, Portugal.ORCID http://orcid.org/0000-0001-7599-7480
Marco MendesSchool of Health Sciences (ESSLei), Polytechnic of Leiria, Leiria, Portugal.ORCID http://orcid.org/0000-0001-7922-4282
Cândida G SilvaCenter for Innovative Care and Health Technology (ciTechCare), Polytechnic of Leiria, Leiria, Portugal.ORCID http://orcid.org/0000-0002-7092-1169
Nuno MoraisCenter for Innovative Care and Health Technology (ciTechCare), Polytechnic of Leiria, Leiria, Portugal.ORCID http://orcid.org/0000-0002-8209-3719
Instituto Politécnico de Leiria · PT

Funding

Fundação para a Ciência e a Tecnologia UIDB/05704/2020
6 · The paper itself

Abstract

purposeTo investigate the effects of exercise training on cancer-related fatigue (CRF) in colorectal cancer survivors.

methodsRandomized controlled trials published between 1 January 2010 and 19 October 2020, selected through online search conducted in PubMed, Scopus, Web of Science, SPORTDiscus and PEDro databases, were included. Eligible trials compared the effect of exercise training interventions, versus non-exercise controls on CRF, in colorectal cancer survivors, during or after treatment. The methodological quality of individual studies was analysed using the Physiotherapy Evidence Database (PEDro) scale. Standardized mean differences (SMD) that were pooled using random-effects models were included as the effect size. In addition, 95% prediction intervals (PI) were calculated.

resultsSix trials involving 330 colorectal cancer patients met the inclusion criteria and presented reasonable to good methodological quality. An overall small-to-moderate effect of exercise training on CRF was found (SMD =  - 0.29: 95% CI: [- 0.53; - 0.06]; p = 0.01; PI: [- 0.63; 0.04]; low-quality evidence). Subgroup analysis revealed moderate effects of exercise interventions performed during chemotherapy (SMD =  - 0.63; 95% CI: [- 1.06; - 0.21]; p = 0.003) and small, non-significant effects, when exercise training was performed after cancer treatment (SMD =  - 0.14; 95% CI: [- 0.43; 0.14]; p = 0.32). Steady improvements were achieved when a combination of aerobic plus resistance exercise was used, in interventions lasting 12 to 24 weeks.

conclusionExercise training could be regarded as a supportive therapy for the clinical management of CRF in colorectal cancer patients undergoing chemotherapy, but further studies are necessary to clarify the effects of exercise interventions on CRF after cancer treatment.

Indexed as

Colorectal NeoplasmsQuality of LifeExerciseExercise TherapyFatigueHumansRandomized Controlled Trials as TopicSurvivorsColorectal cancerExercise trainingFatigueOncologyPhysical activityRehabilitation

Identifiers

PMID35107601
OpenAlexW4210658701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.