ArticleNeuroradiology2022
Regional Homogeneity Alterations in Patients with Impaired Consciousness. An Observational Resting-State fMRI Study.
Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 14 citations in OpenAlex.
- Intrinsic Brain Activity Alterations in Disorders of Consciousness: A Parallel Resting-State fMRI Analysis at 7 Tesla.Brain topography · 2026Article
- Article
- Analysis of the microstates of prolonged disorders of consciousness.Frontiers in neurology · 2025Article
- Covert cortical processing: a diagnosis in search of a definition.Neuroscience of consciousness · 2024Article
- Altered regional neural activity and functional connectivity in patients with non-communicating hydrocephalus: a resting-state functional magnetic resonance imaging study.Frontiers in neurology · 2024Article
- Study of a precise treatment protocol for patients with consciousness disorders based on the brain network analysis of functional magnetic resonance imaging.Frontiers in neuroscience · 2024Article
- Functional networks in prolonged disorders of consciousness.Frontiers in neuroscience · 2023Review
- Electroencephalogram-Based Brain Connectivity Analysis in Prolonged Disorders of Consciousness.Neural plasticity · 2023Article
- Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity.Frontiers in neuroscience · 2022Article
- Altered functional connectivity and regional brain activity in a triple-network model in minimally conscious state and vegetative-state/unresponsive wakefulness syndrome patients: A resting-state functional magnetic resonance imaging study.Frontiers in behavioral neuroscience · 2022Article
- Multimodal MRI reveals three-tiered pathological co-alterations in prolonged disorders of consciousness: structural disconnection, network disintegration, and regional hyperconnectivity.Frontiers in neurologyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt is always challenging to correctly differentiate between minimally conscious state (MCS) and vegetative state/unresponsive wakefulness syndrome (VS/UWS) among disorders of consciousness (DOC) patients. However, the underlying neural mechanisms of awareness identification remain incompletely understood.
methodsUsing regional homogeneity (ReHo) analysis, we evaluated how regional connectivity of brain regions is disrupted in MCS and VS/UWS patients. Resting-state functional magnetic resonance imaging was conducted in 14 MCS patients, 25 VS/UWS patients, and 30 age-matched healthy individuals.
resultsWe found that MCS and VS/UWS patients demonstrated DOC-dependent reduced ReHo within widespread brain regions including posterior cingulate cortices (PCC), medial prefrontal cortices (mPFC), and bilateral fronto-parieto-temporal cortices and showed increased ReHo in limbic structures. Moreover, a positive correlation between Coma Recovery Scale-Revised (CRS-R) total scores and reduced ReHo in the left precuneus was observed in VS/UWS patients, despite the linear trend was not found in MCS patients. In addition, ReHo were also observed reduced in three mainly intrinsic connectivity networks (ICNs), including default mode network (DMN), executive control network (ECN), and salience network (SN). Notably, as the clinical symptoms of consciousness disorders worsen from MCS to VS/UWS, ReHo in dorsal DMN, left ECN, and posterior SN became significantly reduced.
conclusionThese findings make a further understanding of the underlying neural mechanism of regional connectivity among DOC patients and provide additional neuroimaging-based biomarkers for the clinical diagnosis of MCS and VS/UWS patients.
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