ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Autonomous Multi-Step and Multi-Objective Optimization Facilitated by Real-Time Process Analytics.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- The Impact of Continuous Flow Technology and Collaboration between Academia and Industry.JACS Au · 2026Review
- Self-driving lab discovers principles for steering spontaneous emission beyond conventional Fourier optics.Nature communications · 2025Article
- Homogeneous catalysis in continuous flow integrating photocatalysis, electrocatalysis, and automation technologies.Communications chemistry · 2025Review
- Machine Learning-Driven Optimization of Continuous-Flow Photoredox Amine Synthesis.Organic process research & development · 2025Article
- Chemical Process Development in the Pharmaceutical Industry in Europe-Insights and Perspectives from Industry Scientists.Angewandte Chemie (International ed. in English) · 2025Review
- Emerging trends in the optimization of organic synthesis through high-throughput tools and machine learning.Beilstein journal of organic chemistry · 2025Review
- Automated Optimization of a Multistep, Multiphase Continuous Flow Process for Pharmaceutical Synthesis.ACS sustainable chemistry & engineering · 2024Article
- IR-EcoSpectra: Exploring sustainableJournal of pharmaceutical analysis · 2024Review
- Simultaneous reaction- and analytical model building using dynamic flow experiments to accelerate process development.Chemical science · 2024Article
- A Slug Flow Platform with Multiple Process Analytics Facilitates Flexible Reaction Optimization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Bayesian Self-Optimization for Telescoped Continuous Flow Synthesis.Angewandte Chemie (International ed. in English) · 2023Article
- Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands.Journal of the American Chemical Society · 2023Article
- A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals.Journal of flow chemistry · 2022Article
- Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds.Communications chemistry · 2022Article
- Bayesian Optimization of Computer-Proposed Multistep Synthetic Routes on an Automated Robotic Flow Platform.ACS central science · 2022Article
- Autonomous Multi-Step and Multi-Objective Optimization Facilitated by Real-Time Process Analytics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Autonomous flow reactors are becoming increasingly utilized in the synthesis of organic compounds, yet the complexity of the chemical reactions and analytical methods remains limited. The development of a modular platform which uses rapid flow NMR and FTIR measurements, combined with chemometric modeling, is presented for efficient and timely analysis of reaction outcomes. This platform is tested with a four variable single-step reaction (nucleophilic aromatic substitution), to determine the most effective optimization methodology. The self-optimization approach with minimal background knowledge proves to provide the optimal reaction parameters within the shortest operational time. The chosen approach is then applied to a seven variable two-step optimization problem (imine formation and cyclization), for the synthesis of the active pharmaceutical ingredient edaravone. Despite the exponentially increased complexity of this optimization problem, the platform achieves excellent results in a relatively small number of iterations, leading to >95% solution yield of the intermediate and up to 5.42 kg L
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.