Evidence map›Paper›PMID 35106666›Full record

ArticleCellular and molecular neurobiology2023

Prognostic Significance of mRNA Expression RBBP8 or Its Methylation in Gliomas.

Zhendong Liu, Xingbo Cheng, Shaochong Lin, Zhibin Han, Haoran Jin, Zheyu Luan, Pengxu Li, Wenjia Liang, Rongjun Qian, Yanzheng Gao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Zhendong Liu *Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, Henan, People's Republic of China.
Xingbo Cheng *Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, Henan, People's Republic of China.
Shaochong Lin *Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People's Republic of China.
Zhibin Han *Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University and Institute of Brain Science, Harbin Medical University, Harbin, 150000, Heilongjiang, People's Republic of China.
Haoran JinDalian Medical University, 9 Western Sections, Lvshun South Street, Lvshunkou District, Dalian, 116044, People's Republic of China.
Zheyu LuanDepartment of Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, 150000, Heilongjiang, People's Republic of China.
Pengxu LiHenan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, Henan, People's Republic of China.
Wenjia LiangDepartment of Neurosurgery of Henan Provincial People's Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, People's Republic of China.
Rongjun QianDepartment of Neurosurgery of Henan Provincial People's Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, People's Republic of China. doctorqianrongjun@163.com.
Yanzheng GaoHenan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, Henan, People's Republic of China. yanzhenggaohn@gs.zzu.edu.cn.ORCID http://orcid.org/0000-0002-2937-815X
Henan University · CNHarbin Medical University · CNDalian Medical University · CNThird Affiliated Hospital of Zhengzhou University · CN

Funding

the thousand talents plan of central plains ZYQR201912122
6 · The paper itself

Abstract

Retinoblastoma-binding protein 8 (RBBP8) affects the prognosis of patients with malignancies through various mechanisms. However, its function in gliomas is unknown. Our study explored the effects of RBBP8 on the prognosis of glioma patients, as well as its regulatory role in the glioma immune microenvironment. We used various bioinformatics methods to analyze the transcriptional profiles and methylation data of RBBP8 in gliomas from multiple databases. Our results showed that the mRNA and protein expression of RBBP8 in gliomas was higher than that in normal tissues and positively correlated with malignant clinical features such as age and WHO grade. A Kaplan-Meier analysis showed that patients with high RBBP8 expression had a poor prognosis. Cox regression demonstrated that RBBP8 was an independent risk indicator and had good diagnostic value for the poor prognosis of glioma. Importantly, RBBP8 was positively correlated with many well-known immune checkpoints (e.g., CTLA4 and PDL-1). Finally, a gene set enrichment analysis revealed that RBBP8 was remarkably enriched in cancer-related pathways such as cell cycle, DNA replication and so on. In conclusion, this study is the first to elaborate on the value of RBBP8 in the pathological process of glioma for anti-tumor immunotherapy. In addition, the expression of RBBP8 and its methylation site, cg05513509, may provide potential targets for glioma therapy.

Indexed as

Brain NeoplasmsGliomaEndodeoxyribonucleasesHumansMethylationPrognosisRNA, MessengerTumor MicroenvironmentEndodeoxyribonucleasesRBBP8 protein, humanRNA, MessengerBiomarkerGliomaImmunotherapyRBBP8

Identifiers

PMID35106666
PMCPMC11415150
OpenAlexW4220810557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.