ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022
Morphological characterization and clinical effects of stromal alterations after intracorneal ring segment implantation in keratoconus.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Clinical Outcomes and Complications After INTACS Implantation in Keratoconus: A Systematic Review.Journal of clinical medicine · 2026Review
- Alteration in epithelium and stroma of Post-INTACS cornea: Ultrastructure and 3D transmission electron tomography.Histology and histopathology · 2026Article
- [Excimer laser-assisted keratoplasty is successful in the management of complex cases of intracorneal ring segments in keratoconus].Die Ophthalmologie · 2025Article
- Femtosecond laser-assisted intracorneal MyoRing explantation - A novel rescue technique.American journal of ophthalmology case reports · 2025Article
- A new technique to implant intracorneal ring-segments from the perilimbal region: one-year prospective pilot study report.BMC ophthalmology · 2024Article
- Ex Vivo Histological Analysis of Corneas with Manually Implanted Intracorneal Stromal Ring Segments.Journal of clinical medicine · 2024Article
- Ocular condition prognosis in Keratoconus patients after corneal ring implantation using artificial neural networks.Heliyon · 2023Article
- ByLimb: Development of a New Technique to Implant Intracorneal Ring-Segments from the Perilimbal Region.Life (Basel, Switzerland) · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the histological and (ultra)structural stromal tissue changes after femtosecond (Fs) laser-assisted intracorneal ring segment (ICRS) implantation and their refractive and topographic effects in patients with keratoconus.
methodsThis monocentric retrospective case series included 15 consecutive patients with clinical peri-segmental lamellar channel deposits after treatment with Fs-ICRS implantation for keratoconus. The stromal changes were investigated using in vivo confocal microscopy. Two patients underwent a penetrating keratoplasty after the Fs-ICRS implantation; the explanted corneas were processed for histopathology and transmission electron microscopy (TEM). Refractive and topographic effects were investigated comparing the uncorrected (UDVA) and corrected (CDVA) distance visual acuity, spherical equivalent (SE), flat (K1), steep (K2), and steepest (Kmax) keratometry before and after detection of lamellar channel deposits.
resultsIn vivo confocal microscopy revealed diffuse linear and focal granular hyperreflective structures. Histologically, there was mild proliferation of fibroblasts and fibrosis. TEM demonstrated focal accumulations of degenerated keratocytes with cytoplasmic lipid inclusions. There were no significant changes for UDVA (Δ = 0.0 ± 0.2 logMAR; p = 0.67), CDVA (Δ = 0.0 ± 0.1 logMAR; p = 0.32), SE (Δ 0.1 ± 0.9 D; p = 0.22), K1 (Δ = 0.3 ± 1.0 D; p = 0.28), K2 (Δ = 0.1 ± 0.9 D; p = 0.51), and Kmax (Δ = 0.3 ± 1.5 D; p = 0.17).
conclusionsTwo types of structural stromal changes were identified: (1) diffuse peri-segmental fibrosis and (2) lamellar channel deposits. These structural changes showed no evidence of a relevant refractive or topographic effect.
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