Evidence map›Paper›PMID 35106625›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022

Neridronate for transient osteoporosis of the hip in a child.

C Gaggiano, M Bardelli, M Tarsia, S Gentileschi, A Maselli, S Grosso, L Cantarini, B Frediani

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. [Imaging in hip disorders in childhood and adolescence].Orthopadie (Heidelberg, Germany) · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

C GaggianoRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Policlinico "Le Scotte", viale Bracci 1, 53100, Siena, Italy. cgaggiano132@gmail.com.ORCID http://orcid.org/0000-0003-1401-8343
M BardelliRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Policlinico "Le Scotte", viale Bracci 1, 53100, Siena, Italy.
M TarsiaClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, Italy.
S GentileschiRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Policlinico "Le Scotte", viale Bracci 1, 53100, Siena, Italy.ORCID http://orcid.org/0000-0001-6658-1037
A MaselliClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, Italy.
S GrossoClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0002-0974-0596
L CantariniRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Policlinico "Le Scotte", viale Bracci 1, 53100, Siena, Italy.ORCID http://orcid.org/0000-0002-7352-1275
B FredianiRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Policlinico "Le Scotte", viale Bracci 1, 53100, Siena, Italy.
University of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient osteoporosis of the hip (TOH) is usually reported in middle-aged men or during pregnancy as a benign self-limiting condition. Nevertheless, its impact on quality of life in terms of pain and disability is considerable. Also, it can lead to insufficiency fractures or, more rarely, evolve into osteonecrosis. This condition is anecdotally described in the pediatric age and very little is known about how it may affect the growing bone. We herein describe a case of TOH in a 10-year-old child treated at our pediatric rheumatology service and summarize the pediatric cases of TOH previously reported in literature. There are two points of interest in our case report, the first one being the unusual complication of TOH with a femoral physis fracture and the second the complete recovery after the off-label therapy with bisphosphonates. We suggest that interventional medical treatment could be considered in selected cases of juvenile TOH, to prevent any possible irreversible damage on the femoral physis. As far as we know, this is the first report of neridronate employment in children affected by TOH.

Indexed as

OsteoporosisQuality of LifeChildDiphosphonatesFemaleHip JointHumansMagnetic Resonance ImagingMaleMiddle AgedPregnancy6-amino-1-hydroxyhexane-1,1-diphosphonateDiphosphonatesBisphosphonatesBone marrow edemaNeridronatePediatric bone diseasesTransient osteoporosis

Identifiers

PMID35106625
PMCPMC9187543
OpenAlexW4210727083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.