ArticleThe Journal of clinical endocrinology and metabolism2022
Population-based Assessment of Cardiometabolic-related Diagnoses in Youth With Klinefelter Syndrome: A PEDSnet Study.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Vascular Ageing in Conditions Associated with Early-Onset Hypogonadism.Journal of vascular research · 2026Article
- Burden of Liver Disease Among Individuals With Turner Syndrome and Klinefelter Syndrome: A Comprehensive Perspective.Chronic diseases and translational medicine · 2026Article
- Multicenter Analysis of Cardiometabolic-Related Diagnoses in Youth With Congenital Adrenal Hyperplasia: A PEDSnet Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Mild liver dysfunction in Klinefelter syndrome is associated with abdominal obesity and elevated lipids but not testosterone treatment.Journal of endocrinological investigation · 2024Article
- Improving child health through Big Data and data science.Pediatric research · 2023Review
- The complications of male hypogonadism: is it just a matter of low testosterone?Frontiers in endocrinology · 2023Review
- Multicenter Analysis of Cardiometabolic-related Diagnoses in Transgender and Gender-Diverse Youth: A PEDSnet Study.The Journal of clinical endocrinology and metabolism · 2022Article
Corrections and comments
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Authors and funding
11 authors at 10 institutions in 1 country.
Funding
Abstract
contextDiabetes and cardiovascular diseases are common among men with Klinefelter syndrome (KS) and contribute to high morbidity and mortality.
objectiveTo determine if cardiometabolic-related diagnoses are more prevalent among youth with KS than matched controls in a large population-based cohort.
methodsSecondary data analysis of electronic health records from 6 pediatric institutions in the United States (PEDSnet). Patients included all youth with KS in the database (n = 1080) and 4497 youth without KS matched for sex, age (mean 13 years at last encounter), year of birth, race, ethnicity, insurance, site, and duration of care (mean 7 years). The main outcome measures were prevalence of 5 cardiometabolic-related outcomes: overweight/obesity, dyslipidemia, dysglycemia, hypertension, and liver dysfunction.
resultsThe odds of overweight/obesity (OR 1.6; 95% CI 1.4-1.8), dyslipidemia (3.0; 2.2-3.9), and liver dysfunction (2.0; 1.6-2.5) were all higher in KS than in controls. Adjusting for covariates (obesity, testosterone treatment, and antipsychotic use) attenuated the effect of KS on these outcomes; however, boys with KS still had 45% greater odds of overweight/obesity (95% CI 1.2-1.7) and 70% greater odds of liver dysfunction (95% CI 1.3-2.2) than controls, and both dyslipidemia (1.6; 1.1-2.4) and dysglycemia (1.8; 1.1-3.2) were higher in KS but of borderline statistical significance when accounting for multiple comparisons. The odds of hypertension were not different between groups.
conclusionThis large, population-based cohort of youth with KS had a higher odds of most cardiometabolic-related diagnoses than matched controls.
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Registered trials
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