Evidence map›Paper›PMID 35106377›Full record

ArticleACS central science2022

Rapid On-Cell Selection of High-Performance Human Antibodies.

David N Philpott, Surath Gomis, Hansen Wang, Randy Atwal, Abdellali Kelil, Tanja Sack, Brandon Morningstar, Chris Burnie, Edward H Sargent, Stephane Angers and 2 more

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. High-throughput protein binder discovery by rapid in vivo selection.bioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Methods for Engineering Binders to Multi-Pass Membrane Proteins.Bioengineering (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

David N PhilpottEdward S. Rogers Sr. Department of Electrical & Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G8, Canada.
Surath GomisEdward S. Rogers Sr. Department of Electrical & Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G8, Canada.
Hansen WangDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Randy AtwalDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Abdellali KelilDonnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Tanja SackDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Brandon MorningstarDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Chris BurnieDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Edward H SargentEdward S. Rogers Sr. Department of Electrical & Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G8, Canada.ORCID https://orcid.org/0000-0003-0396-6495
Stephane AngersDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Sachdev SidhuDonnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Shana O KelleyDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.ORCID https://orcid.org/0000-0003-3360-5359
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phage display is a critical tool for developing antibodies. However, existing approaches require many time-consuming rounds of biopanning and screening of potential candidates due to a high rate of failure during validation. Herein, we present a rapid on-cell phage display platform which recapitulates the complex

Identifiers

PMID35106377
PMCPMC8796304
OpenAlexW4200540769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.