Evidence map›Paper›PMID 35105976›Full record

ReviewNature reviews. Clinical oncology2022

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.

Matt Lechner, Jacklyn Liu, Liam Masterson, Tim R Fenton

Registry-linked trialAbstract readReview
In one paragraph

Review in Nature reviews. Clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07565740 (A Prospective, Single-Arm Clinical Study of Intranasal Recombinant Adenovirus Vaccine WSK-IM05 Combined With Tislelizumab as Neoadjuvant Therapy for HPV-Positive Oropharyngeal Squamous Cell Carcinoma), which is not on this map. Cited by 543 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
543citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07565740 phase1recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective, Single-Arm Clinical Study of Intranasal Recombinant Adenovirus Vaccine WSK-IM05 Combined With Tislelizumab as Neoadjuvant Therapy for HPV-Positive Oropharyngeal Squamous Cell Carcinoma

TypeinterventionalSponsorWest China HospitalRan2026 to 2028Enrolled9ConditionsHPV-positive Oropharyngeal Squamous Cell CarcinomaArmsWSK-IM05 (4×10^10 vp), WSK-IM05 (8×10^10 vp), WSK-IM05 (1.6x10^11 vp), Tislelizumab
3 · Its place in the literature

Who cites it

543 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  6. A Meta-analysis of Functional Outcomes and Recovery Metrics Comparing Transoral Robotic Surgery and (Chemo)Radiotherapy.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
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  20. Genetic susceptibility, risk prediction, and druggable targets for oropharyngeal cancer: a UK Biobank study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article

483 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Matt LechnerUCL Cancer Institute, University College London, London, UK. m.lechner@ucl.ac.uk.ORCID 0000-0002-7123-0773
Jacklyn LiuUCL Cancer Institute, University College London, London, UK.
Liam MastersonDepartment of ENT, Cambridge University Hospitals NHS Trust, Cambridge, UK.
Tim R FentonSchool of Biosciences, University of Kent, Canterbury, UK. t.fenton@soton.ac.uk.ORCID 0000-0002-4737-8233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV)-positive (HPV

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsOropharyngeal NeoplasmsPapillomavirus InfectionsHumansMolecular EpidemiologyQuality of LifeSquamous Cell Carcinoma of Head and Neck

Identifiers

PMID35105976
PMCPMC8805140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.