ArticleNeurology(R) neuroimmunology & neuroinflammation2022
Humoral and Cellular Responses to SARS-CoV-2 in Convalescent COVID-19 Patients With Multiple Sclerosis.
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In one paragraph
Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- COVID-19: The Course, Vaccination and Immune Response in People with Multiple Sclerosis: Systematic Review.International journal of molecular sciences · 2023Pooled it
- Integrated Assessment of Humoral and Cellular SARS-CoV-2 Immunity Using ELISA and a Gold Nanoparticle-Based IGRA.International journal of molecular sciences · 2026Article
- Humoral and Cellular Immunity After Vaccination Against SARS-CoV-2 in Relapsing-Remitting Multiple Sclerosis Patients Treated with Interferon Beta and Dimethyl Fumarate.Biomedicines · 2025Article
- Seroprevalence of SARS-CoV-2 in Patients with Multiple Sclerosis under Disease-Modifying Therapies: A Multi-Centre Study.Journal of clinical medicine · 2023Article
- Risk of breakthrough COVID-19 after vaccination among people with multiple sclerosis on disease-modifying therapies.Journal of neurology · 2023Article
- T cell responses to COVID-19 infection and vaccination in patients with multiple sclerosis receiving disease-modifying therapy.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Review
- Article
- Ocrelizumab Impairs the Phenotype and Function of Memory CD8Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Donor selection for adoptive cell therapy with CD45RACytotherapy · 2023Article
- Effectiveness of BBIBP-CorV vaccine in preventing SARS-CoV2 infection and severe outcomes in people living with multiple sclerosis: A population-based study.Multiple sclerosis and related disorders · 2023Observational
- Ocrelizumab effect on humoral and cellular immunity in multiple sclerosis and its clinical correlates: a 3-year observational study.Journal of neurology · 2023Observational
- Article
- Risk and severity of SARS-CoV-2 reinfection among patients with multiple sclerosis vs. the general population: a population-based study.BMC neurology · 2022Article
- Multiple Sclerosis Treatment in the COVID-19 Era: A Risk-Benefit Approach.Neurology international · 2022Review
- Immunocompetence after SARS-CoV-2 Infection in a Patient with Multiple Sclerosis Treated with Ofatumumab: A Case Report.Case reports in neurologyArticle
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Authors and funding
33 authors at 1 institution in 1 country.
Ana ZabalzaFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain. azabalza@cem-cat.org.ORCID 0000-0003-3860-5251
Georgina ArrambideFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-2657-5510
Paula TaglianiFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-4048-7314
Simón Cárdenas-RobledoFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-7612-3985
Susana Otero-RomeroFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-1451-6927
Juliana EsperalbaFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0003-1326-1341
Candela Fernandez-NavalFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-5584-3537
Jesus Trocoli CampuzanoFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.
Mónica Martínez GalloFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-7340-2161
Mireia CastilloFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-8979-3219
Mercè BonastreFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.
Mireia Resina SallésFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-9080-0399
Jordina BeltranFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.
Pere Carbonell-MirabentFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.
Marta Rodríguez-BarrancoFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-5454-3041
Samuel López-MazaFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.
Pedro José Melgarejo OtáloraFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.
Mariano Ruiz-OrtizFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-9993-1865
Agustin PappollaFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-6364-9497
Breogán Rodríguez AcevedoFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-0314-753X
Luciana MidagliaFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-7981-2228
Angela Vidal-JordanaFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-7270-5507
Alvaro Cobo-CalvoFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-2574-0721
Carmen TurFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0003-1849-3184
Ingrid GalánFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-5774-4260
Joaquín CastillóFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-8951-6315
Jordi RíoFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0003-4546-7627
Carmen EspejoFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-9949-5901
Manuel ComabellaFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-2373-6657
Carlos NosFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-3830-4910
Jaume Sastre-GarrigaFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-1589-2254
Mar TintoreFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-9999-5359
Xavier MontalbanFrom the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Department (S.O.-R.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona; Microbiology Department (J.E., C.F.-N., J.T.C.), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona; Immunology Division (M.M.G.), Hospital Universitari Vall d'Hebron and Diagnostic Immunology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona; Department of Neurology (P.J.M.O.), Hospital General Universitario Gregorio Marañón, Madrid; and Department of Neurology (M.R.-O.), Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-0098-9918
MACOM (United States) · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesInformation about humoral and cellular responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and antibody persistence in convalescent (COVID-19) patients with multiple sclerosis (PwMS) is scarce. The objectives of this study were to investigate factors influencing humoral and cellular responses to SARS-CoV-2 and its persistence in convalescent COVID-19 PwMS.
methodsThis is a retrospective study of confirmed COVID-19 convalescent PwMS identified between February 2020 and May 2021 by SARS-CoV-2 antibody testing. We examined relationships between demographics, MS characteristics, disease-modifying therapy (DMT), and humoral (immunoglobulin G against spike and nucleocapsid proteins) and cellular (interferon-gamma [IFN-γ]) responses to SARS-CoV-2.
resultsA total of 121 (83.45%) of 145 PwMS were seropositive, and 25/42 (59.5%) presented a cellular response up to 13.1 months after COVID-19. Anti-CD20-treated patients had lower antibody titers than those under other DMTs ( DISCUSSION: Humoral and cellular responses to SARS-CoV-2 are present in COVID-19 convalescent PwMS up to 13.10 months after COVID-19. The humoral response decreases under anti-CD20 treatment, although the cellular response can be detected in anti-CD20-treated patients, even in the absence of antibodies.
Indexed as
Immunity, CellularImmunity, HumoralAdultAgedAntibodies, ViralAntigens, CD20COVID-19FemaleHumansImmunoglobulin GInterferon-gammaMaleMiddle AgedMultiple SclerosisNucleocapsidRetrospective StudiesAntibodies, ViralAntigens, CD20Immunoglobulin GInterferon-gamma
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