Evidence map›Paper›PMID 35105667›Full record

SynthesisJournal of psychiatry & neuroscience : JPN

Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis.

Zhangzhang Qi, Junjing Wang, Jiaying Gong, Ting Su, Siying Fu, Li Huang, Ying Wang

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhangzhang QiFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China (Qi, Su, Fu, Huang, Y. Wang); the Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China (Qi, Su, Fu, Huang, Y. Wang); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (J. Wang); and the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong).
Junjing WangFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China (Qi, Su, Fu, Huang, Y. Wang); the Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China (Qi, Su, Fu, Huang, Y. Wang); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (J. Wang); and the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong) johneil@vip.sina.com.
Jiaying GongFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China (Qi, Su, Fu, Huang, Y. Wang); the Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China (Qi, Su, Fu, Huang, Y. Wang); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (J. Wang); and the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong).
Ting SuFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China (Qi, Su, Fu, Huang, Y. Wang); the Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China (Qi, Su, Fu, Huang, Y. Wang); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (J. Wang); and the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong).
Siying FuFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China (Qi, Su, Fu, Huang, Y. Wang); the Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China (Qi, Su, Fu, Huang, Y. Wang); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (J. Wang); and the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong).
Li HuangFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China (Qi, Su, Fu, Huang, Y. Wang); the Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China (Qi, Su, Fu, Huang, Y. Wang); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (J. Wang); and the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong).
Ying WangFrom the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China (Qi, Su, Fu, Huang, Y. Wang); the Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China (Qi, Su, Fu, Huang, Y. Wang); the Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China (J. Wang); and the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSchizophrenia and bipolar disorder have been linked to alterations in the functional activity and grey matter volume of some brain areas, reflected in impaired regional homogeneity and aberrant voxel-based morphometry. However, because of variable findings and methods used across studies, identifying patterns of brain alteration in schizophrenia and bipolar disorder has been difficult.

methodsWe conducted a meta-analysis of differences in regional homogeneity and voxel-based morphometry between patients and healthy controls for schizophrenia and bipolar disorder separately, using seed-based

resultsWe included 45 publications on regional homogeneity (26 in schizophrenia and 19 in bipolar disorder) and 190 publications on voxel-based morphometry (120 in schizophrenia and 70 in bipolar disorder). Patients with schizophrenia showed increased regional homogeneity in the frontal cortex and striatum and the supplementary motor area; they showed decreased regional homogeneity in the insula, primary sensory cortex (visual and auditory cortices) and sensorimotor cortex. Patients with bipolar disorder showed increased regional homogeneity in the frontal cortex and striatum; they showed decreased regional homogeneity in the insula. Patients with schizophrenia showed decreased grey matter volume in the superior temporal gyrus, inferior frontal gyrus, cingulate cortex and cerebellum. Patients with bipolar disorder showed decreased grey matter volume in the insula, cingulate cortex, frontal cortex and thalamus. Overlap analysis showed that patients with schizophrenia displayed decreased regional homogeneity and grey matter volume in the left insula and left superior temporal gyrus; patients with bipolar disorder displayed decreased regional homogeneity and grey matter volume in the left insula. LIMITATIONS: The small sample size for our subgroup analysis (unmedicated versus medicated patients and substantial heterogeneity in the results for some regions could limit the interpretability and generalizability of the results.

conclusionPatients with schizophrenia and bipolar disorder shared a common pattern of regional functional and structural alterations in the insula and frontal cortex. Patients with schizophrenia showed more widespread functional and structural impairment, most prominently in the primary sensory motor areas.

Indexed as

Bipolar DisorderSchizophreniaBrainGray MatterHumansMagnetic Resonance Imaging

Identifiers

PMID35105667
PMCPMC8812718

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.