Evidence map›Paper›PMID 35105447›Full record

ArticleFertility and sterility2022

Association between uterine fibroids and antimüllerian hormone concentrations among African American women.

Lia A Bernardi, Anne Waldo, Veronica J Berrocal, Lauren A Wise, Erica E Marsh

Open access · greenAbstract read
In one paragraph

Article in Fertility and sterility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Lia A BernardiDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Anne WaldoDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Veronica J BerrocalDepartment of Statistics, University of California, Irvine, California.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Erica E MarshDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan. Electronic address: marshee@med.umich.edu.
Boston University · USNorthwestern University · USUniversity of California, Irvine · USUniversity of Michigan–Ann Arbor · US

Funding

Uterine LeiomyomasZIAES049013 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JUKIC, ANNE MARIE · 2009 to 2025
$14.7M
Study of Ovarian Aging and Reserve in Young Women (SOAR)R01HD088638 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARSH, ERICA E · 2017 to 2022
$3.1M
Intramural NIH HHS ZIA ES049013NICHD NIH HHS R01 HD088638
6 · The paper itself

Abstract

objectiveTo evaluate the extent to which uterine fibroids are associated with antimüllerian hormone (AMH) concentrations.

designCross-sectional study.

settingBaseline data from the Study of the Environment, Lifestyle, and Fibroids, which is a 5-year longitudinal study of African American women. PATIENT(S): A total of 1,643 women aged 23-35 years without a known history of fibroids. EXPOSURE: Fibroid presence. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The primary outcome was percent difference in the mean AMH concentration between participants with fibroids and those without fibroids. The secondary outcomes were percent differences in the mean AMH concentrations in participants with different numbers, sizes, types, and positions of fibroids and the percent difference in the mean AMH concentration in participants with different uterine volumes. RESULT(S): At least 1 fibroid was identified on ultrasound in 362 (22%) participants. There was a small difference in the mean AMH concentrations in participants with fibroids (age-adjusted model: -4.6%, 95% confidence interval (CI): -14.5% to 6.5%; multivariable model: -4.6%, 95% CI: -14.4% to 6.3%). The mean AMH concentrations were found to decrease with increasing fibroid number. Although differences in AMH concentrations were not statistically significant, compared with no fibroids, the mean percent differences in AMH concentrations for 1, 2-3, and ≥4 fibroids were -1.2% (95% CI: -13.2% to 12.5%), -7.1% (95% CI: -23.3% to 12.5%), and -17.5% (95% CI: -38.2% to 10.0%), respectively. There were no consistent associations between AMH concentrations and fibroid location, size, or uterine volume. CONCLUSION(S): The presence of fibroids was not materially associated with AMH concentrations. Other than a monotonic inverse relationship between fibroid number and AMH concentrations, no other fibroid characteristics were consistently or appreciably associated, although associations were imprecise.

Indexed as

LeiomyomaUterine NeoplasmsAdultAnti-Mullerian HormoneBlack or African AmericanCross-Sectional StudiesFemaleHumansLongitudinal StudiesYoung AdultAnti-Mullerian HormoneAntimüllerian hormoneovarian reserveuterine fibroidsuterine leiomyomas

Identifiers

PMID35105447
PMCPMC8983564
OpenAlexW4210741496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.