Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors at 4 institutions in 2 countries.
Gerard R Hall *School of Life Sciences, University of Nottingham, United Kingdom (G.R.H., R.C.T., M.D.W., T.D.F.).ORCID 0000-0002-7694-7490
Philipp Boehm-Sturm *Department of Experimental Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin (P.B.-S., U.D., M.F., C.H., S.P.K., S.M., C.S., T.D.F.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.ORCID 0000-0001-8777-4823
Ulrich DirnaglDepartment of Experimental Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin (P.B.-S., U.D., M.F., C.H., S.P.K., S.M., C.S., T.D.F.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.ORCID 0000-0003-0755-6119
Carsten FinkeDepartment of Neurology (C.F., J.K.), Charité-Universitätsmedizin Berlin, Germany.ORCID 0000-0002-7665-1171
Marco FoddisDepartment of Experimental Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin (P.B.-S., U.D., M.F., C.H., S.P.K., S.M., C.S., T.D.F.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.ORCID 0000-0003-3354-6790
Christoph HarmsDepartment of Experimental Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin (P.B.-S., U.D., M.F., C.H., S.P.K., S.M., C.S., T.D.F.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.ORCID 0000-0002-2063-2860
Stefan Paul KochDepartment of Experimental Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin (P.B.-S., U.D., M.F., C.H., S.P.K., S.M., C.S., T.D.F.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.ORCID 0000-0001-6606-6369
Joseph KuchlingExperimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin (J.K.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.ORCID 0000-0002-7981-2073
Christopher R MadanSchool of Psychology, University of Nottingham, United Kingdom (C.R.M.).ORCID 0000-0003-3228-6501
Susanne MuellerDepartment of Experimental Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin (P.B.-S., U.D., M.F., C.H., S.P.K., S.M., C.S., T.D.F.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.ORCID 0000-0002-5053-2211
Celeste SassiDepartment of Experimental Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin (P.B.-S., U.D., M.F., C.H., S.P.K., S.M., C.S., T.D.F.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.ORCID 0000-0002-2837-1765
Stamatios N SotiropoulosSir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, United Kingdom (S.N.S.).ORCID 0000-0003-4735-5776
Rebecca C TruemanSchool of Life Sciences, University of Nottingham, United Kingdom (G.R.H., R.C.T., M.D.W., T.D.F.).
Marcus D WallisSchool of Life Sciences, University of Nottingham, United Kingdom (G.R.H., R.C.T., M.D.W., T.D.F.).ORCID 0000-0001-9244-5864
Tracy D FarrSchool of Life Sciences, University of Nottingham, United Kingdom (G.R.H., R.C.T., M.D.W., T.D.F.).ORCID 0000-0002-6781-5226
Humboldt-Universität zu Berlin · DEUniversity of Nottingham · GBCharité - Universitätsmedizin Berlin · DEGerman Center for Neurodegenerative Diseases · DE
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundConnectome analysis of neuroimaging data is a rapidly expanding field that offers the potential to diagnose, characterize, and predict neurological disease. Animal models provide insight into biological mechanisms that underpin disease, but connectivity approaches are currently lagging in the rodent.
methodsWe present a pipeline adapted for structural and functional connectivity analysis of the mouse brain, and we tested it in a mouse model of vascular dementia.
resultsWe observed lacunar infarctions, microbleeds, and progressive white matter change across 6 months. For the first time, we report that default mode network activity is disrupted in the mouse model. We also identified specific functional circuitry that was vulnerable to vascular stress, including perturbations in a sensorimotor, visual resting state network that were accompanied by deficits in visual and spatial memory tasks.
conclusionsThese findings advance our understanding of the mouse connectome and provide insight into how it can be altered by vascular insufficiency.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features. · full record | OpenQuestion