Evidence map›Paper›PMID 35105173›Full record

ArticleCirculation. Cardiovascular quality and outcomes2022

Exposure to Neighborhood-Level Racial Residential Segregation in Young Adulthood to Midlife and Incident Subclinical Atherosclerosis in Black Adults: The Coronary Artery Risk Development in Young Adults Study.

Naveen M Reddy, Stephanie L Mayne, Lindsay R Pool, Penny Gordon-Larsen, John Jeffrey Carr, James G Terry, Kiarri N Kershaw

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trajectory of longitudinal lending discrimination modifies the efficacy of a skills-based intervention in stroke survivors.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Naveen M ReddyDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (N.M.R., S.L.M., L.R.P., K.N.K.).
Stephanie L MayneDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (N.M.R., S.L.M., L.R.P., K.N.K.).ORCID 0000-0003-1674-9537
Lindsay R PoolDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (N.M.R., S.L.M., L.R.P., K.N.K.).
Penny Gordon-LarsenDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA (S.L.M.).ORCID 0000-0001-5322-4188
John Jeffrey CarrDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN (J.J.C., J.G.T.).ORCID 0000-0002-4398-8237
James G TerryDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN (J.J.C., J.G.T.).ORCID 0000-0001-6659-3441
Kiarri N KershawDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (N.M.R., S.L.M., L.R.P., K.N.K.).ORCID 0000-0002-0063-6397
Northwestern University · USVanderbilt University Medical Center · USChildren's Hospital of Philadelphia · US

Funding

Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9M
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS R01 HL143885
6 · The paper itself

Abstract

backgroundNeighborhood-level racial residential segregation has been linked to several cardiovascular disease risk factors and outcomes in Black adults, but its impact on subclinical atherosclerosis remains unknown. In addition, although the impact of segregation on health may vary over the life course, most studies have examined segregation exposure at a single point in time. This article takes a life course approach by examining associations of exposure to neighborhood-level racial residential segregation in young adulthood and patterns of exposure from young adulthood to midlife with coronary artery calcification (CAC) incidence.

methodsWe used data on 1125 Black CARDIA study (Coronary Artery Risk Development in Young Adults) participants free of CAC. Residential segregation was assessed using the G

resultsWe found participants living in low segregation neighborhoods in young adulthood had 0.52 (rate ratio [95% CI: 0.28-0.98]) times lower risk of developing CAC compared with high segregation after adjusting for young adulthood sociodemographic characteristics and neighborhood poverty. Associations were attenuated and no longer statistically significant with adjustment for midlife CAC risk factors hypothesized to be on the causal pathway (rate ratio: 0.56 [95% CI: 0.29-1.09]). Findings for patterns of segregation over time suggest participants living in low segregation neighborhoods in young adulthood were less likely to develop CAC than those who started out in medium/high segregation neighborhoods, regardless of where they lived in midlife (rate ratio for increase from low to medium/high: 0.42 [95% CI: 0.19-0.95]; rate ratio for continuously low versus continuously medium/high segregation neighborhoods: 0.75 [95% CI: 0.31-1.83]).

conclusionsWe found that participants living in more segregated neighborhoods in young adulthood were more likely to develop CAC due at least in part to differences in CAC risk factor burden accumulated over follow-up.

Indexed as

AtherosclerosisCoronary Artery DiseaseSocial SegregationAdolescentAdultHumansResidence CharacteristicsYoung Adultatherosclerosisepidemiologyincidenceresidence characteristicsrisk factors

Identifiers

PMID35105173
PMCPMC10792596
OpenAlexW4210334811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.