Evidence map›Paper›PMID 35104659›Full record

ReviewCurrent opinion in insect science2022

Evolution and loss of ß-catenin and TCF-dependent axis specification in insects.

Urs Schmidt-Ott, Yoseop Yoon

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in insect science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Urs Schmidt-OttUniversity of Chicago, Dept. of Organismal Biology and Anatomy, 1027 East 57th Street, Chicago, IL 60637, USA. Electronic address: uschmid@uchicago.edu.
Yoseop YoonUniversity of California, Irvine, Dept. of Microbiology and Molecular Genetics, School of Medicine, 811 Health Sciences Rd., Med Sci B262, CA 92617, USA.
University of California, Irvine · USUniversity of Chicago · US

Funding

Genetic variation and function of body axis determinants in midges and other fliesR01GM127366 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHMIDT-OTT, URS C · 2018 to 2025
$2.3M
NIGMS NIH HHS R01 GM127366
6 · The paper itself

Abstract

Mechanisms and evolution of primary axis specification in insects are discussed in the context of the roles of ß-catenin and TCF in polarizing metazoan embryos. Three hypotheses are presented. First, insects with sequential segmentation and posterior growth use cell-autonomous mechanisms for establishing embryo polarity via the nuclear ratio of ß-catenin and TCF. Second, TCF homologs establish competence for anterior specification. Third, the evolution of simultaneous segmentation mechanisms, also known as long-germ development, resulted in primary axis specification mechanisms that are independent of ß-catenin but reliant on TCF, a condition that preceded the frequent replacement of anterior determinants in long germ insects.

Indexed as

beta CateninBody PatterningAnimalsCateninsGene Expression Regulation, DevelopmentalInsectabeta CateninCatenins

Identifiers

PMID35104659
PMCPMC9133022
OpenAlexW4210470433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.