ArticleNeurobiology of disease2022
Quantifying seizure termination patterns reveals limited pathways to seizure end.
Article in Neurobiology of disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 23 citations in OpenAlex.
- Feature library for behavioural characterization of early and late seizures in an experimental model of post-traumatic epilepsy.Journal of neuroscience methods · 2026Article
- Thalamocortical network dynamics in focal epilepsy: SEEG investigation.bioRxiv : the preprint server for biology · 2026Article
- Inter-seizure variability in thalamic recruitment and its implications for precision thalamic neuromodulation.Communications medicine · 2025Article
- The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.Neuroscience bulletin · 2025Review
- DREDge: robust motion correction for high-density extracellular recordings across species.Nature methods · 2025Article
- The role of the thalamus in focal human epilepsy: insights from stereoelectroencephalography (SEEG).Frontiers in neurology · 2025Review
- A Nonlinear Method to Identify Seizure Dynamic Trajectory Based on Variance of Recurrence Rate in Human Epilepsy Patients Using EEG.Journal of medical signals and sensors · 2025Article
- Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures.bioRxiv : the preprint server for biology · 2024Article
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Article
- DREDge: robust motion correction for high-density extracellular recordings across species.bioRxiv : the preprint server for biology · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Modular pipeline for reconstruction and localization of implanted intracranial ECoG and sEEG electrodes.PloS one · 2023Article
- Review
- Focal seizures are organized by feedback between neural activity and ion concentration changes.eLife · 2022Article
- Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex.Nature neuroscience · 2022Article
- Multiple mechanisms shape the relationship between pathway and duration of focal seizures.Brain communications · 2022Article
- Mechanisms of Neurostimulation for Epilepsy.Epilepsy currentsArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveDespite their possible importance in the design of novel neuromodulatory approaches and in understanding status epilepticus, the dynamics and mechanisms of seizure termination are not well studied. We examined intracranial recordings from patients with epilepsy to differentiate seizure termination patterns and investigated whether these patterns are indicative of different underlying mechanisms.
methodsSeizures were classified into one of two termination patterns: (a) those that end simultaneously across the brain (synchronous), and (b) those whose termination is piecemeal across the cortex (asynchronous). Both types ended with either a burst suppression pattern, or continuous seizure activity. These patterns were quantified and compared using burst suppression ratio, absolute energy, and network connectivity.
resultsSeizures with electrographic generalization showed burst suppression patterns in 90% of cases, compared with only 60% of seizures which remained focal. Interestingly, we found similar absolute energy and burst suppression ratios in seizures with synchronous and asynchronous termination, while seizures with continuous seizure activity were found to be different from seizures with burst suppression, showing lower energy during seizure and lower burst suppression ratio at the start and end of seizure. Finally, network density was observed to increase with seizure progression, with significantly lower densities in seizures with continuous seizure activity compared to seizures with burst suppression. SIGNIFICANCE: Based on this spatiotemporal classification scheme, we suggest that there are a limited number of seizure termination patterns and dynamics. If this bears out, it would imply that the number of mechanisms underlying seizure termination is also constrained. Seizures with different termination patterns exhibit different dynamics even before their start. This may provide useful clues about how seizures may be managed, which in turn may lead to more targeted modes of therapy for seizure control.
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