SynthesisChest2022
Genetic Associations and Architecture of Asthma-COPD Overlap.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Multi-omics study to elucidate molecular mechanism of polyhexamethylene guanidine phosphate (PHMG-p)-induced pulmonary damage in mice.Archives of toxicology · 2026Article
- Genetic Evidence for Unified Airway Disease: Shared Epithelial and Immune Architecture Across Major Airway Diseases.International journal of molecular sciences · 2026Article
- Integrative Multivariate Genomics Identifies Shared Epithelial-Immune and Cytokine-Regulatory Mechanisms Across Major Chronic Lung Diseases.International journal of molecular sciences · 2026Article
- The therapeutic effects of dupilumab in asthma-chronic obstructive pulmonary disease overlap and pure asthma: a pilot study.Journal of thoracic disease · 2026Article
- The evolving global burden of asthma among children and adolescents, 1990-2040: trends, disparities, and future projections based on Global Burden of Disease (GBD) 2021.Journal of thoracic disease · 2026Article
- Genome-wide Association Study IdentifiesAllergy, asthma & immunology research · 2026Article
- Review
- Article
- Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025Review
- lncRNALife science alliance · 2025Article
- Bidirectional genetic links between chronic obstructive pulmonary disease and frailty: Genome-wide association study insights.PloS one · 2025Article
- Temporal trends and future projections of incidence rate and mortality for asthma in China: an analysis of the Global Burden of Disease Study 2021.Frontiers in medicine · 2025Article
- Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024Review
- Genome-wide association study identifies novel susceptible loci and evaluation of polygenic risk score for chronic obstructive pulmonary disease in a Taiwanese population.BMC genomics · 2024Article
- Shared genetic aetiology of respiratory diseases: a genome-wide multitraits association analysis.BMJ open respiratory research · 2024Article
- Common Pathogeneses Underlying Asthma and Chronic Obstructive Pulmonary Disease -Insights from Genetic Studies.International journal of chronic obstructive pulmonary disease · 2024Review
- Asthma exacerbations and eosinophilia in the UK Biobank: a genome-wide association study.ERJ open research · 2024Article
- Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease.The Journal of allergy and clinical immunology · 2023Article
- Revealing polygenic pleiotropy using genetic risk scores for asthma.HGG advances · 2023Article
- Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study.Nature communications · 2023Article
Corrections and comments
- Commented on by
Authors and funding
54 authors at 20 institutions in 9 countries.
Catherine JohnDepartment of Health Sciences, University of Leicester, Leicester, England. Electronic address: cj153@leicester.ac.uk.
Anna L GuyattDepartment of Health Sciences, University of Leicester, Leicester, England.
Nick ShrineDepartment of Health Sciences, University of Leicester, Leicester, England.
Richard PackerDepartment of Health Sciences, University of Leicester, Leicester, England.
Thorunn A OlafsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.
Jiangyuan LiuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Lystra P HaydenChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Su H ChuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jukka T KoskelaInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, England.
Xingnan LiDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ.
Natalie TerzikhanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Hanfei XuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Traci M BartzCardiovascular Health Research Unit, Department of Medicine and Department of Biostatistics, University of Washington, Seattle, WA.
Hans PetersenLovelace Respiratory Research Institute, Albuquerque, NM.
Shuguang LengDivision of Epidemiology, Biostatistics, and Preventive Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM.
Steven A BelinskyLovelace Respiratory Research Institute, Albuquerque, NM.
Aivaras CepelisDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Levanger, Norway.
Ana I Hernández CorderoCentre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Ma'en ObeidatCentre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Gudmar ThorleifssondeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Deborah A MeyersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ.
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ.
Lori C SakodaDivision of Research, Kaiser Permanente of Northern California, Oakland, CA.
Carlos IribarrenDivision of Research, Kaiser Permanente of Northern California, Oakland, CA.
Yohannes TesfaigziBrigham and Women's Hospital and Harvard Medical School, Boston, MA.
Sina A GharibComputational Medicine Core, Center for Lung Biology and UW Medicine Sleep Center, Medicine, University of Washington, Seattle, WA.
Josée DupuisCardiovascular Health Research Unit, Department of Medicine and Department of Biostatistics, University of Washington, Seattle, WA.
Guy BrusselleDepartment of Biostatistics, Boston University School of Public Health, Boston, MA; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Lies LahousseDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Bioanalysis, Ghent University, Ghent, Belgium.
Victor E OrtegaDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Ingileif JonsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Don D SinCentre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Yohan BosséInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec, QC, Canada.
Maarten van den BergeDepartment of Pulmonology, University Medical Center Groningen, University of Groningen, and GRIAC Research Institute, Groningen, the Netherlands.
David NickleGlobal Health, University of Washington, Seattle, WA; Gossamer Bio, San Diego, CA.
Jennifer K QuintNational Heart and Lung Institute, Imperial College London, London, UK.
Ian SayersDivision of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, England; Biodiscovery Institute, University of Nottingham, Nottingham, England.
Ian P HallDivision of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, England.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, England.
Samuli RipattiInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Broad Institute of MIT and Harvard, Cambridge, MA.
Tarja LaitinenDivision of Medicine, Department of Pulmonary Diseases, Turku University Hospital, Turku, Finland; Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
Ann C WuCenter for Healthcare Research in Pediatrics (CHeRP) and PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA.
Jessica Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Per BakkeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Amund GulsvikDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
Arnulf LanghammerDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Levanger, Norway.
Ben BrumptonK. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Clinic of Thoracic and Occupational Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Louise V WainDepartment of Health Sciences, University of Leicester, Leicester, England; Leicester NIHR Biomedical Research Centre, Leicester, England.
Martin D TobinDepartment of Health Sciences, University of Leicester, Leicester, England; Leicester NIHR Biomedical Research Centre, Leicester, England.
Brigham and Women's Hospital · USUniversity of Leicester · GBUniversity of Washington · USdeCODE Genetics (Iceland) · ISHarvard University · USNorwegian University of Science and Technology · NOUniversity of Arizona · USUniversity of British Columbia · CAErasmus MC · NLKaiser Permanente · USLovelace Respiratory Research Institute · USMRC Epidemiology Unit · GBUniversity of Bergen · NOBoston University · USFinland University · FIGhent University Hospital · BEImperial College London · GBInstitute of Genetics and Cancer · GBNIHR Leicester Biomedical Research Centre · GBNottingham Biomedical Research Centre · GB
Funding
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MEffects of Rare Variants and Ancestry on Beta Agonist Response in Asthma and COPDR01HL142992 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ORTEGA, VICTOR E. · 2019 to 2023
$3.7MGenetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5MIdentifying functional variants in COPD GWAS lociR01HL137927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2017 to 2020
$3.5MGenetic Epidemiology of Respiratory Function in Former Preterm ChildrenK23HL136851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAYDEN, LYSTRA P. · 2018 to 2022
$969kIntegrative metabolomic characterization of ADHD and asthma comorbidityK01HL153941 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHU, SU HEE · 2020 to 2024
$891kBritish Heart Foundation AA/18/3/34220Department of HealthMedical Research Council G1000861Medical Research Council MC_PC_17228Medical Research Council MC_PC_19004Medical Research Council MC_QA137853Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00007/10Medical Research Council MR/N011317/1Medical Research Council MR/P00167X/1NHLBI NIH HHS K01 HL153941NHLBI NIH HHS K23 HL136851NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01 HL142992NHLBI NIH HHS R01 HL147148Wellcome Trust 202849/Z/16/ZWellcome Trust 204801/Z/16/ZWellcome Trust WT202849/Z/16/Z
Abstract
backgroundSome people have characteristics of both asthma and COPD (asthma-COPD overlap), and evidence suggests they experience worse outcomes than those with either condition alone. RESEARCH QUESTION: What is the genetic architecture of asthma-COPD overlap, and do the determinants of risk for asthma-COPD overlap differ from those for COPD or asthma? STUDY DESIGN AND
methodsWe conducted a genome-wide association study in 8,068 asthma-COPD overlap case subjects and 40,360 control subjects without asthma or COPD of European ancestry in UK Biobank (stage 1). We followed up promising signals (P < 5 × 10
resultsWe selected 31 independent variants for further investigation in stage 2, and discovered eight novel signals (P < 5 × 10
interpretationWe identified eight signals for asthma-COPD overlap, which may represent loci that predispose to type 2 inflammation, and serious long-term consequences of asthma.
Indexed as
AsthmaPulmonary Disease, Chronic ObstructiveGenome-Wide Association StudyHumansLungSmokingasthmaCOPDepidemiologygenome-wide association studyspirometry
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.