ArticleAmerican journal of respiratory and critical care medicine2022
Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06152653 (The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC), which is not on this map. Cited by 78 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
14.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT06152653 phase4active not recruitingnot on this mapstarted 2024, after this paper: background citation
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC
Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review.Respiratory research · 2026Pooled it
- Effect of Tezepelumab on Lung Function in Patients With Severe, Uncontrolled Asthma in the Phase 3 NAVIGATOR Study.Advances in therapy · 2023Trial
- Restoring the Airway Barrier: How Targeting Eosinophilic Inflammation Shapes Epithelial Health and Clinical Remission in Asthma.Diagnostics (Basel, Switzerland) · 2026Review
- Review
- Respiratory Support in Pediatric Critical and Near-Fatal Asthma: A Narrative Review.Pulmonary therapy · 2026Review
- Is Asthma Remission a New Achievable Goal? A Review of the Current Drug-Related Evidence and Predictors.Allergy · 2026Review
- Effectiveness of mepolizumab on mucus plugs and clinical outcomes in severe eosinophilic asthma with and without coexisting bronchiectasis: a prospective pilot study.ERJ open research · 2026Article
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and implications for clinical trials.American journal of respiratory and critical care medicine · 2026Review
- Characterization of mucus plugging in patients with chronic obstructive pulmonary disease: additional clinical significance of asthma-like features.BMC pulmonary medicine · 2026Article
- 3D CT-Based quantification of airway structural changes during asthma exacerbations: a retrospective observational study.BMC pulmonary medicine · 2026Observational
- Artificial Intelligence-Based Detection of Airway Mucus Plugs on CT and Associations With Clinical Outcomes in COPDGene.medRxiv : the preprint server for health sciences · 2026Article
- Mucus Plugging as a Treatable Trait Across the Asthma-COPD Spectrum: The Role of Type 2 Cytokine Blockade and Quantitative Imaging.Biomedicines · 2026Review
- Review
- Asthma endotypes and theratypes.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Airway mucus plugs in COPD clinical phenotypes and prognosis across stable and exacerbation states.Scientific reports · 2026Article
- Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026Article
- When asthmatic distal airways lose their identity: a new mechanism of mucus plugs pathogenesis.American journal of respiratory and critical care medicine · 2026Article
- Progress in treating mucus plugs in asthma.American journal of respiratory and critical care medicine · 2026Article
- Is blood eosinophilia a treatable trait in chronic obstructive airway diseases?Frontiers in immunology · 2026Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 13 institutions in 3 countries.
Monica TangDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine.
Brett M ElickerDepartment of Radiology and Biomedical Imaging, and.
Travis HenryDuke Radiology, Department of Radiology, Duke University, Durham, North Carolina.
David S GieradaMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Mark L SchieblerDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Brendan K HuangDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine.
Michael C PetersDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine.
Mario CastroDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, Kansas.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, Iowa.
Sean B FainDepartment of Radiology, University of Iowa, Iowa City, Iowa.
Samuel Y AshDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Jiwoong ChoiDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, Kansas.
Chase HallDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, Kansas.
Brenda R PhillipsCenter for Biostatistics and Epidemiology, Pennsylvania State University School of Medicine, Harrisburg, Pennsylvania.
David T MaugerDivision of Biostatistics and Bioinformatics, Penn State College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania.
Loren C DenlingerDivision of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Nizar N JarjourDivision of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Elliot IsraelDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Wanda PhipatanakulAsthma, Allergy, Dermatology, Rheumatology, and Immunology, Boston Children's Hospital, Boston, Massachusetts.
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Sally E WenzelDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Eugene R BleeckerDepartment of Medicine, University of Arizona College of Medicine, Tucson, Arizona.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine.
John V FahyDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine.
Eleanor M DunicanEducation and Research Centre, St. Vincent's University Hospital, Dublin, Ireland; and.
Brigham and Women's Hospital · USUniversity of Kansas · USUniversity of Wisconsin–Madison · USPennsylvania State University · USUniversity of California, San Francisco · USUniversity of Iowa · USBoston Children's Hospital · USDuke University · USLaboratoire d’Imagerie Biomédicale · FRMallinckrodt (United States) · USUniversity College Dublin · IEUniversity of Arizona · USUniversity of Pittsburgh · US
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3MRapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3MProtein carbohydrate interactions in the pathophysiology of asthma exacerbationsR01HL080414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John V Fahy · 2005 to 2026
$9.2MClinical Coordinating Center for the Severe Asthma Research Program (SARP)U10HL109086 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2011 to 2017
$8.1MAMSA: ALXR/FBR Mediated Signaling in Severe AsthmaU10HL109172 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, LEVY, BRUCE D · 2011 to 2016
$4.2MAirway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2MClinical and Molecular Phenotypes of Severe AsthmaU10HL109146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2011 to 2016
$4.0MImplications and Stability of Clinical and Molecular Phenotypes of Severe AsthmaU10HL109152 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WENZEL, SALLY E · 2011 to 2016
$3.9MStability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9MSevere Asthma Research Program (SARP)-Washington UniversityU10HL109257 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2011 to 2016
$3.8MNHLBI NIH HHS F32 HL162422NHLBI NIH HHS K24 HL137013NHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL080414NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257NIAID NIH HHS U19 AI077439NIEHS NIH HHS P30 ES005605NIH HHS S10 OD025214
Abstract
PubMed holds no abstract for this paper.
Indexed as
AsthmaMucusCross-Sectional StudiesHumansLungRespiratory Function Testsair trappingasthmacomputed tomographyeosinophilsmucus plugs
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06152653ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.