Evidence map›Paper›PMID 35104433›Full record

ArticleOpen biology2022

Recurrence of COVID-19 associated with reduced T-cell responses in a monozygotic twin pair.

Mateus V de Castro, Keity S Santos, Juliana S Apostolico, Edgar R Fernandes, Rafael R Almeida, Gabriel Levin, Jhosiene Y Magawa, João Paulo S Nunes, Mirian Bruni, Marcio M Yamamoto and 21 more

Open access · goldAbstract readTwin Study
In one paragraph

Article in Open biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Immunological evaluation of young unvaccinated patients with Turner syndrome after COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 5 institutions in 1 country.

Mateus V de CastroHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-8895-652X
Keity S SantosLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.ORCID 0000-0001-5271-4011
Juliana S ApostolicoInstitute for Investigation in Immunology-Instituto Nacional de Ciência e Tecnologia-iii-INCT, São Paulo, SP, Brazil.ORCID 0000-0002-3507-3117
Edgar R FernandesInstitute for Investigation in Immunology-Instituto Nacional de Ciência e Tecnologia-iii-INCT, São Paulo, SP, Brazil.ORCID 0000-0001-5981-5149
Rafael R AlmeidaLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.ORCID 0000-0003-3984-7527
Gabriel LevinLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.ORCID 0000-0002-6527-7989
Jhosiene Y MagawaLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
João Paulo S NunesLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.ORCID 0000-0003-4355-6669
Mirian BruniDepartment of Parasitology, Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Marcio M YamamotoDepartment of Parasitology, Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Ariane C LimaLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
Monize V R SilvaHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Larissa R B MatosHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Vivian R CoriaHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Erick C CastelliSchool of Medicine, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
Marilia O ScliarHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Andreia KuramotoLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
Fernanda R BrunoLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
Lucas C JacinthoLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
Kelly NunesHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Jaqueline Y T WangHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Veronica P CoelhoLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
Miguel Mitne NetoFleury Laboratory, São Paulo, SP, Brazil.
Rui M B MacielFleury Laboratory, São Paulo, SP, Brazil.
Michel S NaslavskyHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Maria Rita Passos-BuenoHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Silvia B BoscardinLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
Daniela S RosaLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
Jorge KalilHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.
Mayana ZatzHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de São Paulo, São Paulo, SP, Brazil.ORCID 0000-0003-3970-8025
Edecio Cunha-NetoLaboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, SP, Brazil.
Universidade de São Paulo · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRFleury S.A. (Brazil) · BRUniversidade Federal de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind the recurrence have not been thoroughly investigated. The presence of neutralizing antibodies (nAbs) in recurrence/reinfection cases suggests that other types of immune response are involved in protection against recurrence. Here, we investigated the innate type I/III interferon (IFN) response, binding and nAb assays and T-cell responses to severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) with IFN gamma (IFN

Indexed as

Immunity, CellularTwins, MonozygoticAdolescentAdultCOVID-19Epitopes, T-LymphocyteFemaleHumansMaleRecurrenceSARS-CoV-2T-LymphocytesEpitopes, T-LymphocyteCOVID-19immunityrecurrencesevere acute respiratory distress syndrome coronavirus 2T celltwins

Identifiers

PMID35104433
PMCPMC8807054
OpenAlexW4210532659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.