Evidence map›Paper›PMID 35104408›Full record

ArticleMolecular pharmaceutics2022

Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by

Johanna Hjalte, Shakhawath Hossain, Andreas Hugerth, Helen Sjögren, Marie Wahlgren, Per Larsson, Dan Lundberg

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Johanna HjalteFood Technology, Engineering and Nutrition, Lund University, Box 124, 221 00 Lund, Sweden.ORCID 0000-0002-2375-8856
Shakhawath HossainDepartment of Pharmacy, Drug Delivery, Uppsala University, Box 580, 751 23 Uppsala, Sweden.ORCID 0000-0001-9556-2695
Andreas HugerthFerring Pharmaceuticals A/S, Amager Strandvej 405, 2770 Kastrup, Denmark.ORCID 0000-0002-7602-0476
Helen SjögrenFerring Pharmaceuticals A/S, Amager Strandvej 405, 2770 Kastrup, Denmark.ORCID 0000-0003-2592-1239
Marie WahlgrenFood Technology, Engineering and Nutrition, Lund University, Box 124, 221 00 Lund, Sweden.ORCID 0000-0002-1705-3964
Per LarssonDepartment of Pharmacy, Drug Delivery, Uppsala University, Box 580, 751 23 Uppsala, Sweden.ORCID 0000-0002-8418-4956
Dan LundbergCR Competence AB, Center for Chemistry and Chemical Engineering, Box 124, 221 00 Lund, Sweden.ORCID 0000-0001-9392-9537

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding of peptide aggregation propensity is an important aspect in pharmaceutical development of peptide drugs. In this work, methodologies based on all-atom molecular dynamics (AA-MD) simulations and

Indexed as

Molecular Dynamics SimulationMagnetic Resonance SpectroscopyProton Magnetic Resonance Spectroscopy1H NMR spectroscopyAA-MD simulationsaggregationevaluation of developabilitytherapeutic peptides

Identifiers

PMID35104408
PMCPMC8905580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.