Evidence map›Paper›PMID 35104381›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2022

Reducing health inequality in Black, Asian and other minority ethnic pregnant women: impact of first trimester combined screening for placental dysfunction on perinatal mortality.

Becky Liu, Usaama Nadeem, Alexander Frick, Morakinyo Alakaloko, Amar Bhide, Basky Thilaganathan

Open access · hybridAbstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Interventions to Address Disparities in Perinatal Outcomes by Ethnicity: A Systematic Review.BJOG : an international journal of obstetrics and gynaecology · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. The Role of Ethnicity and Migration in Perinatal Inequalities: A Retrospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Disparities in Stillbirths in England: Analysis of A Population-Based Study of 1.3 Million Births.BJOG : an international journal of obstetrics and gynaecology · 2025
    Observational
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Pre-eclampsia.Nature reviews. Disease primers · 2023
    Review
  17. Article
  18. Placental dysfunction screening and perinatal loss.BJOG : an international journal of obstetrics and gynaecology · 2022
    Article
  19. Preventing Stillbirth: A Review of Screening and Prevention Strategies.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Becky LiuFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-4968-8294
Usaama NadeemVascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK.
Alexander FrickFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
Morakinyo AlakalokoFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
Amar BhideFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
Basky ThilaganathanFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-5531-4301
St George's, University of London · GBSt George’s University Hospitals NHS Foundation Trust · GB

Funding

Biorithm Pte Ltd
6 · The paper itself

Abstract

objectiveTo assess the impact of the Fetal Medicine Foundation (FMF) first trimester screening algorithm for pre-eclampsia on health disparities in perinatal death among minority ethnic groups.

designA retrospective cohort study from July 2016 to December 2020.

settingA large London teaching hospital. PATIENTS AND

methodsAll women who underwent first trimester pre-eclampsia risk assessment using either the NICE screening checklist or the FMF multimodal approach. Women considered at high-risk in the FMF cohort were offered 150 mg aspirin before 16 weeks' gestation, serial growth scans and elective birth at 40 weeks.

main outcome measuresStillbirth, neonatal death and perinatal death rates stratified by screening method and maternal ethnicity.

resultsIn the NICE cohort, the perinatal death rate was significantly higher in non-white than white women (7.95 versus 2.63/1000 births, OR 3.035, 95% CI 1.551-5.941). Following the introduction of FMF screening, the perinatal death rate in non-white women fell from 7.95 to 3.22/1000 births (OR 0.403, 95% CI 0.206-0.789), such that it was no longer significantly different from the perinatal mortality rate in white women (3.22 versus 2.55/1000 births, OR 1.261, 95% CI 0.641-2.483).

conclusionsFirst trimester combined screening for placental dysfunction is associated with a significant reduction in perinatal death in minority ethnic women. Health disparities in perinatal death among ethnic minority women demand urgent attention from both clinicians and health policy makers. The data of this study suggest that this ethnic health inequality may be avoidable. TWEETABLE ABSTRACT: Multimodal early pregnancy placental dysfunction screening can lead to a significant reduction in perinatal deaths in non-white women.

Indexed as

Perinatal DeathPre-EclampsiaEthnicityFemaleHealth Status DisparitiesHumansInfant, NewbornMinority GroupsPerinatal MortalityPlacentaPregnancyPregnancy Trimester, FirstPregnant PeopleRetrospective StudiesStillbirthearly screeningethnicityneonatal deathperinatal deathplacental dysfunctionpre-eclampsiastillbirth

Identifiers

PMID35104381
PMCPMC9544950
OpenAlexW4210715078

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.