Evidence map›Paper›PMID 35104367›Full record

ArticlePhotochemistry and photobiology2022

Wavelength-dependent DNA Photodamage in a 3-D human Skin Model over the Far-UVC and Germicidal UVC Wavelength Ranges from 215 to 255 nm.

David Welch, Marilena Aquino de Muro, Manuela Buonanno, David J Brenner

Abstract read
In one paragraph

Article in Photochemistry and photobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  9. Far-UVC Radiation for Disinfecting Hands or Gloves?Pathogens (Basel, Switzerland) · 2023
    Article
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  17. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David WelchCenter for Radiological Research, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0003-2784-496X
Marilena Aquino de MuroCenter for Radiological Research, Columbia University Irving Medical Center, New York, NY.
Manuela BuonannoCenter for Radiological Research, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-3455-3602
David J BrennerCenter for Radiological Research, Columbia University Irving Medical Center, New York, NY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effectiveness of UVC to reduce airborne-mediated disease transmission is well established. However, conventional germicidal UVC (~254 nm) cannot be used directly in occupied spaces because of the potential for damage to the skin and eye. A recently studied alternative with the potential to be used directly in occupied spaces is far UVC (200-235 nm, typically 222 nm), as it cannot penetrate to the key living cells in the epidermis. Optimal far-UVC use is hampered by limited knowledge of the precise wavelength dependence of UVC-induced DNA damage, and thus we have used a monochromatic UVC exposure system to assess wavelength-dependent DNA damage in a realistic 3-D human skin model. We exposed a 3-D human skin model to mono-wavelength UVC exposures of 100 mJ/cm

Indexed as

Anti-Infective AgentsSkinDNADNA DamageEpidermisHumansUltraviolet RaysAnti-Infective AgentsDNA

Identifiers

PMID35104367
PMCPMC9544172

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.