ArticleACS nano2022
Nanofibril Alignment during Assembly Revealed by an X-ray Scattering-Based Digital Twin.
Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Advances and Clinical Translation Potentials of Functional Nanomaterials in Tissue Engineering.Bioengineering (Basel, Switzerland) · 2026Review
- Transformative roles of digital twins from drug discovery to continuous manufacturing: pharmaceutical and biopharmaceutical perspectives.International journal of pharmaceutics: X · 2025Review
- Tuning Alignment, Strength, and Toughness in Functional Cellulose:Helux Filaments: A Molecular Trade-Off.Biomacromolecules · 2025Article
- Confinement-Induced Self-Assembly of Protein Nanofibrils Probed by Microfocus X-ray Scattering.The journal of physical chemistry. B · 2025Article
- Enhanced High Thermal Conductivity Cellulose Filaments via Hydrodynamic Focusing.Nano letters · 2022Article
- Biomimetic nanomaterial-facilitated oxygen generation strategies for enhancing tumour treatment outcomes.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nanostructure, primarily particle orientation, controls mechanical and functional (e.g., mouthfeel, cell compatibility, optical, morphing) properties when macroscopic materials are assembled from nanofibrils. Understanding and controlling the nanostructure is therefore an important key for the continued development of nanotechnology. We merge recent developments in the assembly of biological nanofibrils, X-ray diffraction orientation measurements, and computational fluid dynamics of complex flows. The result is a digital twin, which reveals the complete particle orientation in complex and transient flow situations, in particular the local alignment and spatial variation of the orientation distributions of different length fractions, both along the process and over a specific cross section. The methodology forms a necessary foundation for analysis and optimization of assembly involving anisotropic particles. Furthermore, it provides a bridge between advanced in operandi measurements of nanostructures and phenomena such as transitions between liquid crystal states and in silico studies of particle interactions and agglomeration.
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Registered trials
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