Evidence map›Paper›PMID 35104013›Full record

ArticleChembiochem : a European journal of chemical biology2022

Synthetic Neoglycoconjugates of Hepta- and Nonamannoside Ligands for Eliciting Oligomannose-Specific HIV-1-Neutralizing Antibodies.

Matteo Cattin, Jean-François Bruxelle, Kurtis Ng, Markus Blaukopf, Ralph Pantophlet, Paul Kosma

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Matteo CattinDepartment of Chemistry, University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, Wien, A-1190, Vienna, Austria.ORCID 0000-0002-4926-3384
Jean-François BruxelleFaculty of Health Sciences and Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A1S6, Canada.
Kurtis NgFaculty of Health Sciences and Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A1S6, Canada.ORCID 0000-0001-7528-4624
Markus BlaukopfDepartment of Chemistry, University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, Wien, A-1190, Vienna, Austria.ORCID 0000-0002-9649-1064
Ralph PantophletFaculty of Health Sciences and Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A1S6, Canada.ORCID 0000-0003-0490-4747
Paul KosmaDepartment of Chemistry, University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, Wien, A-1190, Vienna, Austria.ORCID 0000-0001-5342-7161
BOKU University · ATSimon Fraser University · CAUniversité Claude Bernard Lyon 1 · FR

Funding

Synthetic bacterial analogs of mammalian oligomannose for eliciting neutralizing antibodies to the high-mannose patch on HIV EnvR01AI134299 · NIAID · SIMON FRASER UNIVERSITY · PI PANTOPHLET, RALPH ALPHONSO · 2017 to 2025
$3.8M
NIAID NIH HHS R01 AI134299
6 · The paper itself

Abstract

Oligomannose-type glycans on the spike protein of HIV-1 constitute relevant epitopes to elicit broadly neutralizing antibodies (bnAbs). Herein we describe an improved synthesis of α- and β-linked hepta- and nonamannosyl ligands that were subsequently converted into BSA and CRM

Indexed as

HIV-1Antibodies, NeutralizingEpitopesHIV AntibodiesHumansLigandsMaleAntibodies, NeutralizingEpitopesHIV AntibodiesLigandsglycoconjugatesglycosylationHIV/AIDSoligomannosidessynthesis

Identifiers

PMID35104013
PMCPMC9108342
OpenAlexW4210278557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.