Evidence map›Paper›PMID 35103964›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Chromatin Immunoprecipitation Sequencing (ChIP-seq) Protocol for Small Amounts of Frozen Biobanked Cardiac Tissue.

Jiayi Pei, Noortje A M van den Dungen, Folkert W Asselbergs, Michal Mokry, Magdalena Harakalova

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jiayi PeiDepartment of Cardiology, Division Heart & Lungs, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands.
Noortje A M van den DungenLaboratory of Clinical Chemistry and Hematology, UMC Utrecht, Utrecht, The Netherlands.
Folkert W AsselbergsDepartment of Cardiology, Division Heart & Lungs, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands.
Michal MokryDepartment of Cardiology, Division Heart & Lungs, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands.
Magdalena HarakalovaDepartment of Cardiology, Division Heart & Lungs, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands. m.harakalova@umcutrecht.nl.
University Medical Center Utrecht · NLUtrecht University · NLHealth Data Research UK · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromatin immunoprecipitation and sequencing (ChIP-seq) is a well-established method to study the epigenetic profile at the genome-wide scale, including histone modifications and DNA-protein interactions. It provides valuable insights to better understand disease mechanisms. Here we present an optimized ChIP-seq protocol suitable for human cardiac tissues, especially the frozen biobanked small biopsy samples.

Indexed as

Chromatin Immunoprecipitation SequencingHistone CodeChromatinChromatin ImmunoprecipitationGenomeHigh-Throughput Nucleotide SequencingHumansProtein Processing, Post-TranslationalChromatinAntibodyCardiac tissuesChromatin immunoprecipitationEnhancersPromotersSequencingSmall biopsy

Identifiers

PMID35103964
OpenAlexW4210556180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.