Evidence map›Paper›PMID 35103929›Full record

SynthesisInternational urology and nephrology2022

The effects of saffron supplementation on the measures of renal function indicators: a systematic review and meta-analysis.

Abdolreza Norouzy, Sara Ghodrat, Leila Sadat Bahrami, Zahra Feizy, Seyyed Mostafa Arabi

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Abdolreza NorouzyDepartment of Nutrition, School of Medicine, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Sara GhodratDepartment of Nutrition, School of Medicine, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Leila Sadat BahramiDepartment of Nutrition, School of Medicine, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra FeizyDepartment of Nutritional Sciences, Texas Tech University, Lubbock, TX, 79414, USA.
Seyyed Mostafa ArabiDepartment of Basic Sciences, School of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran. Mostafa.Arabi.NU@gmail.com.ORCID http://orcid.org/0000-0002-6876-7828
Mashhad University of Medical Sciences · IRTexas Tech University · USUniversity of Neyshabur · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextSaffron (Crocus sativus L.) has been proposed as a potential agent to improve renal function in animal studies. But, due to insufficient evidence in human research, further investigation is needed.

objectiveTo fill this knowledge gap, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of saffron supplementation on the measures of renal function indicators in adults. Renal function was assessed based on serum urea, blood urea nitrogen, and creatinine levels. METHOD AND MATERIALS: A systematic search in PubMed/Medline, Scopus, Web of Science, Embase, and Google Scholar databases was done until March 2021 using relevant keywords. A random-effects model was used to estimate the weighted mean difference (WMD) and 95% confidence (95% CI). Nine RCTs were included in the meta-analysis, and their quality was assessed using the Cochrane risk of bias tool.

resultsThe pooled analysis showed that saffron supplementation had no significant effect on serum urea concentrations (WMD: - 1.05 mg/dl; 95% CI - 5.1 to 3; P = 0.6, I

conclusionsBased on our findings, Saffron supplementation had no significant effect on renal function markers, including urea and creatinine. However, further trials are required to determine the actual effect and safety of saffron intervention in human studies. PROSPERO SUBMISSION ID: 248081.

Indexed as

CrocusAdultCreatinineDietary SupplementsHumansKidneyUreaCreatinineUreaBlood urea nitrogenCreatinineMeta-analysisPharmaceuticalRenal functionSaffronSystematic reviewUrea

Identifiers

PMID35103929
OpenAlexW4210526136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.