Evidence map›Paper›PMID 35103897›Full record

ArticleMolecular biology reports2022

Up-regulated lncRNA-PVT1 expression in peripheral blood mononuclear cells of patients with coronary artery disease is correlated with decreased interleukin-10 production.

Peyman Nowrouzi-Sohrabi, Atefeh Seghatoleslam, Mehdi Kalani, Mehran Erfani, Alireza Hosseini Abgir, Shekoufeh Hatami, Mahdi Namdar, Mohammadjavad Tahmasebi, Behnoosh Miladpour

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Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Peyman Nowrouzi-SohrabiDepartment of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-9720-2025
Atefeh SeghatoleslamDepartment of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-8277-6608
Mehdi KalaniStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-7091-6466
Mehran ErfaniDepartment of Biochemistry, School of Medicine, Hormozgan University of Medical Sciences, Hormozgan, Iran.ORCID http://orcid.org/0000-0001-9593-5383
Alireza Hosseini AbgirDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Fars, Iran.
Shekoufeh HatamiDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Fars, Iran.
Mahdi NamdarDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Fars, Iran.
Mohammadjavad TahmasebiDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Fars, Iran.
Behnoosh MiladpourDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Fars, Iran. miladpour90@yahoo.com.ORCID http://orcid.org/0000-0002-1978-1201
Fasa University of Medical Sciences · IRShiraz University of Medical Sciences · IRHormozgan University of Medical Sciences · IR

Funding

fasa university of medical sciences 97093
6 · The paper itself

Abstract

objectivesPlasmacytoma variant translocation 1 (PVT1) is a newly discovered long non-coding RNA, which has not been previously studied in the inflammatory responses of the peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD). MATERIALS AND

methodsThis cross-sectional study was conducted on 15 CAD patients and 15 non-CAD (NCAD) individuals. The PVT1 expression was assessed in the PBMCs of the participants using a real-time polymerase chain reaction. Interleukin (IL)-10, IL-22, and matrix metalloproteinase-9 (MMP-9) were measured in the plasma and supernatant of cultured PBMCs in the presence or absence of lipopolysaccharide (LPS) using flow cytometry and enzyme-linked immunosorbent assay.

resultsAn increased expression of PVT1 was observed in the untreated PBMCs of CAD patients, compared to the NCAD group. The PVT1 was significantly up-regulated after LPS treatment in the PBMCs of both groups. Plasma MMP-9 levels were found to be higher in CAD patients than in the control individuals. The level of IL-10 and IL-22 production by the non-treated PBMCs of CAD cases was significantly lower than the NCAD group. Overall, in the examined population, PVT1 expression was negatively correlated with IL-10 secretion. Moreover, the results showed a significant negative correlation between PVT1 expression and IL-10 production by untreated cells.

conclusionsThe PVT1 expression augmented in the PBMCs of CAD patients, which could be associated with the decreased IL-10 generation by the PBMCs of these patients.

Indexed as

Coronary Artery DiseaseInterleukin-10RNA, Long NoncodingCross-Sectional StudiesHumansLeukocytes, MononuclearLipopolysaccharidesMatrix Metalloproteinase 9Interleukin-10LipopolysaccharidesMatrix Metalloproteinase 9PVT1 long-non-coding RNA, humanRNA, Long NoncodingCoronary artery diseaseInterleukin-10Long non-coding RNAPVT1

Identifiers

PMID35103897
OpenAlexW4210545846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.