Evidence map›Paper›PMID 35103859›Full record

ArticleBrain structure & function2022

Properties of the epileptiform activity in the cingulate cortex of a mouse model of LIS1 dysfunction.

E Domínguez-Sala, A Andreu-Cervera, P Martín-Climent, R Murcia-Ramón, S Martínez, Emilio Geijo-Barrientos

Open access · hybridAbstract read
In one paragraph

Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

E Domínguez-SalaInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Campus de San Juan, C/Ramón y Cajal sn, San Juan de Alicante, 03550, Alicante, Spain. dominguezsala@gmail.com.ORCID http://orcid.org/0000-0002-8436-9993
A Andreu-CerveraInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Campus de San Juan, C/Ramón y Cajal sn, San Juan de Alicante, 03550, Alicante, Spain.ORCID http://orcid.org/0000-0001-8883-2757
P Martín-ClimentInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Campus de San Juan, C/Ramón y Cajal sn, San Juan de Alicante, 03550, Alicante, Spain.
R Murcia-RamónInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Campus de San Juan, C/Ramón y Cajal sn, San Juan de Alicante, 03550, Alicante, Spain.
S MartínezInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Campus de San Juan, C/Ramón y Cajal sn, San Juan de Alicante, 03550, Alicante, Spain.ORCID http://orcid.org/0000-0002-9320-4103
Emilio Geijo-BarrientosInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Campus de San Juan, C/Ramón y Cajal sn, San Juan de Alicante, 03550, Alicante, Spain. emilio.geijo@umh.es.ORCID http://orcid.org/0000-0001-8655-0967
Universitat de Miguel Hernández d'Elx · ES

Funding

Generalitat Valenciana 2018/041Ministerio de Economía, Industria y Competitividad, Gobierno de España PID2020-118171RB-I00Ministerio de Economía, Industria y Competitividad, Gobierno de España SAF2017-83702-RMinisterio de Economía, Industria y Competitividad, Gobierno de España SEV-2017-0723
6 · The paper itself

Abstract

Dysfunction of the LIS1 gene causes lissencephaly, a drastic neurological disorder characterized by a deep disruption of the cortical structure. We aim to uncover alterations of the cortical neuronal networks related with the propagation of epileptiform activity in the Lis1/sLis1 mouse, a model lacking the LisH domain in heterozygosis. We did extracellular field-potential and intracellular recordings in brain slices of the anterior cingulate cortex (ACC) or the retrosplenial cortex (RSC) to study epileptiform activity evoked in the presence of bicuculline (10 µM), a blocker of GABA

Indexed as

Gyrus CinguliPyramidal Cells1-Alkyl-2-acetylglycerophosphocholine EsteraseAnimalsBicucullineDisease Models, AnimalMiceMicrotubule-Associated ProteinsReceptors, AMPA1-Alkyl-2-acetylglycerophosphocholine EsteraseBicucullineMicrotubule-Associated ProteinsPafah1b1 protein, mouseReceptors, AMPAAMPA receptorsAnterior cingulate cortexCortical circuitsEpileptiform activityLissencephalyRetrosplenial cortex

Identifiers

PMID35103859
PMCPMC9098610
OpenAlexW4210660900

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.