ArticleSocial psychiatry and psychiatric epidemiology2022
Early childhood adversity and late-life depressive symptoms: unpacking mediation and interaction by adult socioeconomic status.
Article in Social psychiatry and psychiatric epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed.
- An alternative to causal mediation for inequality research: which questions can be answered?Social psychiatry and psychiatric epidemiology · 2026Article
- Adverse Childhood Experiences and Life Course Adversity Related to Geriatric Syndromes: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Complex associations of adverse childhood and adulthood experiences with incident depressive symptoms in middle-aged and older Chinese adults.BMC psychology · 2026Article
- Job Stress, Psychological Distress, and Menstruation-Related Symptoms in Female Workers: A Cross-Sectional Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Problematic online gaming mediates the association between attention-deficit/hyperactivity and subsequent mental health issues in adolescents.Communications psychology · 2025Article
- Examining lifestyle factors as potential moderators of the link between childhood adversity and comorbid psychological distress and obesity in early adulthood.BMC public health · 2025Article
- The long-term effects of adverse childhood experiences on adult health and behaviors: mediating role of socioeconomic inequality.BMC public health · 2025Article
- Association between school bullying and late-life depression: Evidence from the China health and retirement longitudinal study.Geriatrics & gerontology international · 2025Article
- The impact of adverse childhood experiences on depression in old age: evidence from China.Frontiers in psychiatry · 2025Article
- Childhood family adversity and recurrent depression in adulthood: the findings of three ELSA-Brasil follow-up visits.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- The Mediating Effects of Chronic Diseases in the Relationship Between Adverse Childhood Experiences and Trajectories of Depressive Symptoms in Later Life: A Nationwide Longitudinal Study.Healthcare (Basel, Switzerland) · 2024Article
- Adverse Childhood Events Significantly Impact Depression and Mental Distress in Adults with a History of Cancer.Cancers · 2024Article
- Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms.Biomedicines · 2024Review
- Childhood socio-economic disadvantages versus adverse care experiences: Mediation and moderation impacts on late-life depressive symptoms.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Estimating the joint association of adverse childhood experiences and asthma with subsequent depressive symptoms: a marginal structural modelling approach.BMJ mental health · 2024Article
- Association of Childhood Adversity With Frailty and the Mediating Role of Unhealthy Lifestyle: A Lifespan Analysis.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Frailty, cognitive impairment, and depressive symptoms in Chinese older adults: an eight-year multi-trajectory analysis.BMC geriatrics · 2023Article
- Life Events, Caregiving, and Risk of Autoimmune Rheumatic Diseases in the Women's Health Initiative Observational Study.Arthritis care & research · 2023Observational
- SuPAR in major depression: Association with 26 weeks antidepressant response and 10-year depression outcomes.Brain, behavior, & immunity - health · 2023Article
- Association of childhood threat and deprivation with depressive symptoms and the moderating role of current economic status among middle-aged and older adults in China.Social psychiatry and psychiatric epidemiology · 2023Article
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Abstract
purposeAdverse childhood experiences (ACEs) have been linked to diminished health achievement across the life course. However, few studies have rigorously investigated the role of adult socioeconomic status (SES) as a mediator and an effect modifier of the association between ACEs and late-life depression. We used a four-way decomposition analysis to examine the relative contributions of mediation and interaction by low adult SES to the association between ACEs and late-life depression.
methodsData came from two waves (2013 and 2016) of the Japan Gerontological Evaluation Study, a nationwide cohort of older people (n = 7271). ACEs were determined as ≥ 2 experiences of the following: parental loss, parental divorce, parental mental illness, domestic violence, physical abuse, psychological neglect, psychological abuse, and economic disadvantage. Low adult SES was defined as earning < 2 million yen of income and < 10 years of schooling. Depressive symptoms were assessed using the Geriatric Depression Scale.
resultsControlled direct effect (coefficient 0.28; 95% CI 0.08-0.46) accounted for 69.1% of the total effect, which was greater than the other three estimates for the decomposed effects (reference interaction 20.8%, mediated interaction 5.7%, and pure indirect effect 4.4%). Adult SES accounted for 10.1% (via mediation) and 26.5% (via exposure-mediator interaction) of the total association between ACEs and depressive symptoms, respectively.
conclusionACEs appeared to be a strong and independent determinant of depressive symptoms in later life. Nonetheless, the interaction between ACEs and adult SES indicates that achieving high adult SES could mitigate the adverse effect of ACEs on late-life depression.
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