ArticleJournal of medical Internet research2022
Patients' Perspectives on Transforming Clinical Trial Participation: Large Online Vignette-based Survey.
Article in Journal of medical Internet research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Factors affecting clinical trial participation in people with interstitial lung disease: a qualitative study.ERJ open research · 2026Article
- Clinical trials in rheumatology: patient motivations and concerns as key determinants of recruitment.Reumatologia · 2026Review
- Do people prefer to take part in a clinical trial from home or come to site? A discrete choice experiment in type 2 diabetes mellitus.BMJ open · 2025Article
- Mapping the rare disease paediatric clinical trial availabilities in Europe.Frontiers in pediatrics · 2025Article
- Article
- Patient and public perspectives of involvement in CV research in Scotland: Heart Engagement And Research Talks.The British journal of cardiology · 2025Article
- Patient engagement and satisfaction with early phase cell therapy clinical trials at a tertiary inflammatory bowel disease center.Stem cell reports · 2024Article
- Article
- Narrative review of telemedicine applications in decentralized research.Journal of clinical and translational science · 2024Review
- Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Decentralized clinical trials in the trial innovation network: Value, strategies, and lessons learned.Journal of clinical and translational science · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients' participation is crucial to the success of randomized controlled trials (RCTs). However, recruiting and retaining patients in trials remain a challenge.
objectiveThis study aims to describe patients' preferences for the organization of RCTs (visits on- site or remotely) and evaluate the potential impact of fulfilling preferences on their willingness to participate in a clinical trial.
methodsThis was a vignette-based survey. Vignettes were case scenarios of real clinical trials assessing pharmacological treatments. These RCTs evaluated 6 prevalent chronic diseases (ie, osteoporosis, osteoarthritis, asthma, cardiovascular diseases, diabetes, and endometriosis). Each vignette described (1) the RCT and characteristics of the treatment tested (ie, doses, administration routes) and (2) the trial procedures and different options (on-site or remotely) for how the trial was organized for informed consent, follow-up visits, and communication of results when the trial was completed. We recruited 628 participants from ComPaRe (www.compare.aphp.fr), a French e-cohort of patients with chronic diseases. The outcomes were the participants' preferences for the way the trial was organized (on-site or remotely) and their willingness to participate in the trial.
resultsOf the 628 participants who answered the vignettes, 491 (78.2%) were female (median age 55 years), with different chronic diseases ranging from endometriosis in 59 of 491 (12%) patients to asthma in 133 of 628 (21.2%) patients. In addition, 38 (6.1%) participants wanted to provide informed consent and all trial visits on-site, 176 (28%) wished to participate in the trial entirely remotely, and 414 (65.9%) wanted to combine remote-based and hospital-based visits. Considering the trial as a whole, when the trial was organized in a way that the patients preferred, the median (Q1-Q3) likelihood of participation in the trial was 90% (80-100) versus 60% (30-80) if the trial followed the patients' nonpreferred model. Furthermore, 256 (40.8%) patients responded to open-ended questions expressing their experience with trial participation and visits to the hospital and providing suggestions for improvement. The patients emphasized the need to personalize the way a trial is organized according to each patient's needs and conditions.
conclusionsThere was a significant diversity in the participants' preferences. Most participants preferred hybrid organization involving both on-site and remote visits. Participants were more likely to participate in a trial organized according to their preferences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.