ArticleAmerican journal of respiratory cell and molecular biology2022
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
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Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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169citing papers in PubMed, 3 pooled it
37.7field-weighted citation impact, top 1% of its field
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Who cites it
169 citing papers in PubMed, 3 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Effect of emodin on acute lung injury: a meta-analysis of preclinical trials.BMC pulmonary medicine · 2024Pooled it
- A preclinical systematic review and meta-analysis assessing the effect of biological sex in lipopolysaccharide-induced acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2024Pooled it
- The therapeutic efficacy of resveratrol for acute lung injury-A meta-analysis of preclinical trials.Frontiers in pharmacology · 2022Pooled it
- A novel curcumin analog sAc15 alleviates LPS-induced acute lung injury by activating the PI3K/AKT/Nrf2 pathway in pulmonary epithelial cells.Redox report : communications in free radical research · 2026Article
- SARS-CoV-2 spike-armed vesicular stomatitis virus recapitulates severe COVID-19 acute respiratory distress syndrome in mice.iScience · 2026Article
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- Norepinephrine attenuates acute lung injury by protecting mitochondria via the βRedox biology · 2026Article
- A developmentally informed narrative review of Toll-like receptors in adult and pediatric acute respiratory distress syndrome.Annals of translational medicine · 2026Review
- Dual knockdown of Scn1b and Gsdmd induces an M2-like functional state in macrophages and modulates inflammation and fibrosis in a rat model of acute respiratory distress syndrome.Molecular biology reports · 2026Article
- A Biofabricated Human Acinus-on-a-Chip Unveils Mechanotransductive Drivers of Ventilator-Induced Lung Injury via Decoupling Volutrauma and Barotrauma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integrated network pharmacology, transcriptomics and proteomics unveils the mechanisms of Forsythiae Fructus against acute lung injury.Die Naturwissenschaften · 2026Article
- Mesenchyme-derived inflammation during the saccular stage recruits macrophages and alters lung development.JCI insight · 2026Article
- Source control within 12 h attenuates lung injury and systemic bacterial burden in a rat model of polymicrobial abdominal sepsis (cecal ligation and puncture).Intensive care medicine experimental · 2026Article
- Dual host and pathogen targeting by MEK1/2 inhibitors.Infection and immunity · 2026Review
- Inhibition of mitochondrial ROS by TACI sustains bone marrow plasma cells.Nature communications · 2026Article
- Hydrolysis and depletion of phosphatidylglycerol at peak murine acute lung injury.Journal of lipid research · 2026Article
- A precision approach to translational research in acute lung injury.American journal of respiratory and critical care medicine · 2026Article
- Necroptosis in alveolar epithelium orchestrates lung ischemia-reperfusion injury: a multi-omics study.Respiratory research · 2026Article
- The comparison of two pendrin inhibitors, YS-01 and PDSinh-C01, in lipopolysaccharide-induced acute lung injury.Scientific reports · 2026Article
- Assessment of Noninvasive Measurement Techniques and Histologic Findings in a Mouse Model of LPS-Induced Acute Lung Injury.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
109 more citing papers are in PubMed but not listed here.
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Authors and funding
50 authors.
Hrishikesh S KulkarniORCID 0000-0003-4830-5084
Janet S LeeORCID 0000-0002-6812-6043
Julie A BastaracheORCID 0000-0003-0458-6507
Wolfgang M KueblerORCID 0000-0003-4100-2961
Gregory P DowneyORCID 0000-0003-3253-5862
Guillermo M AlbaicetaORCID 0000-0002-9276-3253
William A Altemeier
Antonio ArtigasORCID 0000-0002-8029-1017
Jason H T BatesORCID 0000-0002-6062-6377
Carolyn S Calfee
Charles S Dela Cruz
Robert P DicksonORCID 0000-0002-6875-4277
Joshua A Englert
Jeffrey I EverittORCID 0000-0003-0273-6284
Michael B FesslerORCID 0000-0002-8262-8613
Andrew E GelmanORCID 0000-0002-0711-6343
Kymberly M GowdyORCID 0000-0002-7227-0697
Steve D GroshongORCID 0000-0002-6280-4704
Susanne Herold
Robert J HomerORCID 0000-0002-2055-5885
Jeffrey C HorowitzORCID 0000-0002-1505-2837
Connie C W HsiaORCID 0000-0003-1995-1407
Kiyoyasu KurahashiORCID 0000-0003-2484-3769
Victor E LaubachORCID 0000-0001-9673-5383
Mark R LooneyORCID 0000-0003-0241-9190
Rudolf LucasORCID 0000-0003-3805-8868
Nilam S MangalmurtiORCID 0000-0002-9146-1608
Anne M Manicone
Thomas R MartinORCID 0000-0002-8193-909X
Sadis MatalonORCID 0000-0003-0683-3700
Michael A MatthayORCID 0000-0003-3039-8155
Daniel F McAuleyORCID 0000-0002-3283-1947
Sharon A McGrath-MorrowORCID 0000-0002-1576-5394
Joseph P MizgerdORCID 0000-0002-4042-3169
Stephanie A MontgomeryORCID 0000-0001-8012-5302
Bethany B MooreORCID 0000-0003-3051-745X
Alexandra NoëlORCID 0000-0001-5634-8151
Carrie E Perlman
John P ReillyORCID 0000-0003-3937-5320
Eric P SchmidtORCID 0000-0002-7360-0504
Shawn J SkerrettORCID 0000-0002-9622-4070
Tomeka L SuberORCID 0000-0002-7062-0278
Charlotte SummersORCID 0000-0002-7269-2873
Benjamin T SurattORCID 0000-0002-4946-029X
Masao TakataORCID 0000-0002-8144-2091
Rubin TuderORCID 0000-0001-9923-607X
Stefan UhligORCID 0000-0003-2332-1280
Martin Witzenrath
Rachel L ZemansORCID 0000-0003-3537-9869
Gutavo Matute-BelloORCID 0000-0001-6710-8495
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MCell Signaling of Host DefenseZIAES102005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FESSLER, MICHAEL B · 2009 to 2025
$41.7MRegulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3MTHE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9MPneumonia BiologyR35HL135756 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2017 to 2023
$6.6MImmunobiology of Lung Injury and FibrosisR35HL144481 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOORE, BETHANY B. · 2019 to 2024
$5.2MMechanisms of host protection against pathogen-secreted proteases in acute lung injuryR01HL136143 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2017 to 2024
$4.4MImmunobiology of the normal and injured lungR35HL161241 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARK ROBERTS LOONEY · 2022 to 2026
$4.2MImproved ventilation of the edematous lungR01HL113577 · NHLBI · THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY · PI PERLMAN, CARRIE E · 2013 to 2021
$3.3MMechanisms and pathogenicity of SARS-CoV-2-induced neutrophil extracellular trapsR01AI160167 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOONEY, MARK ROBERTS · 2021 to 2025
$3.1MDissecting the molecular mechanisms of lung injury during mechanical ventilationR01HL142767 · NHLBI · OHIO STATE UNIVERSITY · PI ENGLERT, JOSHUA A · 2021 to 2025
$2.8MStructural Plasticity in Compensatory Lung Growth and RemodelingR01HL134373 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HSIA, CONNIE C. W. · 2017 to 2020
$2.8MNCATS NIH HHS UL1 TR001863NHLBI NIH HHS K08 HL148510NHLBI NIH HHS K24 HL143285NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL094601NHLBI NIH HHS R01 HL113577NHLBI NIH HHS R01 HL131608NHLBI NIH HHS R01 HL134373NHLBI NIH HHS R01 HL136143NHLBI NIH HHS R01 HL138410NHLBI NIH HHS R01 HL142084NHLBI NIH HHS R01 HL142767NHLBI NIH HHS R01 HL144656NHLBI NIH HHS R01 HL147920NHLBI NIH HHS R35 HL135756NHLBI NIH HHS R35 HL144481NHLBI NIH HHS R35 HL161241NIAID NIH HHS R01 AI125445NIAID NIH HHS R01 AI160167NIEHS NIH HHS R01 ES028829Wellcome Trust
Abstract
Advancements in methods, technology, and our understanding of the pathobiology of lung injury have created the need to update the definition of experimental acute lung injury (ALI). We queried 50 participants with expertise in ALI and acute respiratory distress syndrome using a Delphi method composed of a series of electronic surveys and a virtual workshop. We propose that ALI presents as a "multidimensional entity" characterized by four "domains" that reflect the key pathophysiologic features and underlying biology of human acute respiratory distress syndrome. These domains are
Indexed as
Acute Lung InjuryAnimalsInflammationResearch Reportextravascular lung waterhypoxialung injurypneumoniarespiratory distress syndrome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.